Activated microglia-derived macrophage-like cells exacerbate brain edema after ischemic stroke correlate with astrocytic expression of aquaporin-4 and interleukin-1 alpha release

Activated microglia-derived macrophage-like cells exacerbate brain edema after ischemic stroke correlate with astrocytic expression of aquaporin-4 and interleukin-1 alpha release

Mind edema following mind infarction impacts mobility and mortality. The mechanisms underlying this course of stay to be elucidated. Animal research have proven that aquaporin-4 (AQP4) expression in astrocytes will increase after stroke, and its deletion considerably reduces mind swelling. Just lately, two sorts of cells, resident microglia-derived macrophage-like cells (MG-MΦ) and bone marrow-derived macrophages (BM-MΦ), have been reported to build up within the ischemic core and stimulate adjoining astrocytes.

Subsequently, we hypothesized that these cells play essential roles within the expression of AQP4 and finally result in exacerbated mind edema. To confirm this speculation, we investigated the position of MG- or BM-MΦ in mind edema utilizing a rat mannequin of transient center cerebral artery occlusion and rat astrocyte main cultures. AQP4 expression considerably elevated within the peri-infarct tissue at 3-7 days post-reperfusion (dpr) and within the core tissue at 5 and seven dpr, which synchronized with the expression of Iba1, Il1a, Tnf, and C1qa mRNA. Interleukin (IL)-1α remedy or coculture with MG- and BM-MΦ elevated AQP4 expression in astrocytes, whereas an IL-1 receptor sort I antagonist diminished these results.

Moreover, aggravated animals exhibited excessive expression of Aqp4 and Il1a mRNA within the ischemic core at 7 dpr, which led to the exacerbation of mind edema. MG-MΦ signature genes have been extremely expressed within the ischemic core in aggravated rats, whereas BM-MΦ signature genes have been weakly expressed. These findings counsel that IL-1α produced by MG-MΦ induces astrocytic AQP4 expression within the peri-infarct and ischemic core tissues, thereby exacerbating mind edema. Subsequently, the regulation of MG-MΦ might forestall the exacerbation of mind edema.

<i>Porphyromonas gingivalis</i>-Induced NLRP3 Inflammasome Activation and Its Downstream <em>Interleukin</em>-1β Launch Rely on Caspase-<em>4</em>

Oral commensals contribute to microbe-host symbiosis in periodontal homeostasis, and Porphyromonas gingivalis (P. gingivalis) because the keystone pathogen critically accounts for the shift of symbiosis to dysbiosis and periodontal destruction. Nucleotide-binding oligomerization area (NOD)-like receptor (NLR) household pyrin area containing 3 (NLRP3) inflammasome-mediated interleukin-1β (IL-1β) is considerably concerned in periodontal illnesses, and notably P. gingivalis permits to modulate the induction and expression of NLRP3. Whereas, the precise mechanism by which NLRP3 inflammasome is regulated in response to commensal and pathogenic micro organism stays unclear.

Strategies: To look at the expression of IL-1β and NLRPs inflammasome in tissues with extreme continual periodontitis, and additional examine how Caspase-4-dependent non-canonical NLRP3 inflammasome pathways functioned throughout the interactions of Streptococcus mitis (S. mitis) and P. gingivalis with human THP-1 cells.

Outcomes: IL-1β and NLRP3, NLRP6, NLRP12, and absent in melanoma 2 (AIM2) inflammasomes are extremely expressed in gingival tissues with extreme continual periodontitis. In human THP-1 cells, P. gingivalis prompts the synthesis and secretion of IL-1β to greater ranges than S. mitis. Importantly, NLRP3-, Caspase-1-, and Caspase-4-siRNA knockdown THP-1 cells handled with P. gingivalis exhibited a decrease expression stage of IL-1β as in comparison with the management cells.

As well as, silencing of both CASP4 or CASP1 can result in a concurrent or reciprocal lower within the expression of the opposite. Of word, the IL-1β induction shouldn’t be affected within the S. mitis-treated THP-1 cells with the silence of NLRP3, Caspase-1, and Caspase-Four genes.

Conclusion: NLRP3/Caspase-Four and NLRP3/Caspase-1 dependent IL-1β manufacturing might crucially contribute to the dysregulated immuno-inflammatory response in periodontal pathogenesis.

Inhibition of Tumor Development towards Chemoresistant Cholangiocarcinoma by a Professional-apoptotic Peptide Focusing on <em>Interleukin</em>-<em>4</em> Receptor

Cholangiocarcinoma (CCA) has a poor prognosis and excessive chemoresistance. Interleukin-Four receptor (IL-4R) is overexpressed in a number of most cancers cells and performs a vital position in tumor development and drug resistance. IL4RPep-1, an IL-4R-binding peptide, has been recognized by phage show and used for tumor-targeting. On this research, we exploited IL4RPep-1 to information the tumor-specific supply of a pro-apoptotic peptide to chemoresistant CCA, thereby inhibiting tumor progress.

Activated microglia-derived macrophage-like cells exacerbate brain edema after ischemic stroke correlate with astrocytic expression of aquaporin-<em>4</em> and <em>interleukin</em>-1 alpha release

Immunohistochemistry of human main CCA tissues confirmed that IL-4R ranges have been upregulated in reasonably to poorly differentiated varieties, and better ranges of IL-4R are correlated with decrease survival price in sufferers with CCA. IL4RPep-1 was noticed to preferentially bind with excessive IL-4R-expressing KKU-213 human CCA cells, whereas it barely sure to low IL-4R-expressing KKU-055 cells.

A hybrid of IL4RPep-1 and a pro-apoptotic peptide (KLAKLAK)2 (named IL4RPep-1-KLA) induced cytotoxicity and apoptosis in KKU-213 cells and elevated these ranges induced by 5-fluorouracil (5-FU). IL4RPep-1-KLA was internalized into the cells and co-localized with mitochondria. Complete-body fluorescence imaging and immunohistochemical evaluation of tumor tissues confirmed the homing of IL4RPep-1-KLA in addition to IL4RPep-1 to KKU-213 tumor in mice.

Systemic administration of IL4RPep-1-KLA effectively inhibited KKU-213 tumor progress, whereas remedy with 5-FU alone didn’t considerably inhibit tumor progress in mice. No vital systemic unintended effects together with liver toxicity and immunotoxicity have been noticed in mice throughout the peptide therapies. These findings counsel that IL4RPep-1-KLA holds potential as a focused therapeutic agent towards chemoresistant CCA.

A Small-Molecule Inhibitor to the Cytokine <em>Interleukin</em>-<em>4</em>

Interleukin-4 (IL-4) is a multifunctional cytokine and an necessary regulator of irritation. When deregulated, IL-Four exercise is related to bronchial asthma, allergic irritation, and a number of sorts of most cancers. Whereas antibody-based inhibitors concentrating on the solu-ble cytokine have been evaluated clinically, they failed to realize their endpoints in trials.

Small-molecule inhibitors are a sexy various, however figuring out efficient chemotypes that inhibit the protein-protein interactions between cytokines and their receptors stays an lively space of analysis. Consequently, no small-molecule inhibitors to the sol-uble IL-Four cytokine have but been reported. Right here, we describe the primary IL-Four small-molecule inhibitor recognized and characterised by way of a mixture of binding-based approaches and cell-based exercise assays.

IL-33 Recombinant Protein

11-180 0.05 mg
EUR 595.25
Description: Interleukin 33 (IL33) is known as C9orf26, DKFZp586H0523, DVS27, NF-HEV, NFEHEV, RP11-575C20.2,and is a cytokine belonging to the IL-1 superfamily. IL-33 induces helper T cells, mast cells, eosinophils and basophils to produce type 2 cytokines. IL-33 mediates its biological effects by interacting with the receptors ST2 (aka IL1RL1) and IL-1 Receptor Accessory Protein (IL1RAP), activating intracellular molecules in the NF-κB and MAP kinase signaling pathways that drive production of type 2 cytokines (e.g. IL-5 and IL-13) from polarized Th2 cells. In vivo, IL-33 induces the expression of IL-4, IL-5, and IL-13 and leads to severe pathological changes in mucosal organs.

IL-31 Recombinant Protein

11-187 0.1 mg
EUR 684.5
Description: IL-31 is an inflammatory cytokine that helps trigger cell-mediated immunity against pathogens. Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA and OSMR. It has also been identified as a major player in a number of chronic inflammatory diseases, including atopic dermatitis. May function in skin immunity. IL-31 is produced by a variety of cells, namely type 2 helper (TH2) T-cells. IL-31 sends signals through a receptor complex made of IL-31RA and oncostatin M receptor β (OSMRβ) expressed in immune and epithelial cells. These signals activate three pathways: ERK1/2 MAP kinase, PI3K/AKT, and JAK1/2 signaling pathways.

IL-33 Recombinant Protein

11-213 0.05 mg
EUR 595.25
Description: Interleukin 33 (IL33) is known as C9orf26, DKFZp586H0523, DVS27, NF-HEV, NFEHEV, RP11-575C20.2,and is a cytokine belonging to the IL-1 superfamily. IL-33 induces helper T cells, mast cells, eosinophils and basophils to produce type 2 cytokines. IL-33 mediates its biological effects by interacting with the receptors ST2 (aka IL1RL1) and IL-1 Receptor Accessory Protein (IL1RAP), activating intracellular molecules in the NF-κB and MAP kinase signaling pathways that drive production of type 2 cytokines (e.g. IL-5 and IL-13) from polarized Th2 cells. In vivo, IL-33 induces the expression of IL-4, IL-5, and IL-13 and leads to severe pathological changes in mucosal organs.

IL-17F Recombinant Protein

11-222 0.05 mg
EUR 595.25
Description: Interleukin-17F (IL17F) is also known as Interleukin-24 (IL24), Cytokine ML-1, is a secreted disulfide-linked homodimer which belongs to the IL-17 family. There are at least six members of the IL-17 family in humans and in mice: IL-17A, IL-17B, IL-17C, IL-17D, IL-17E (also called IL-25) and IL-17F (also called IL-24). IL-17 represents a family of structurally related cytokines that share a highly conserved C-terminal region but differ from one another in their N-terminal regions and in their distinct biological roles. IL-17F / IL-24 is expressed in activated, but not resting, CD4+ T-cells and activated monocytes. IL17F / Interleukin-24 stimulates the production of other cytokines such as IL-6, IL-8 and granulocyte colony-stimulating factor, and can regulate cartilage matrix turnover. IL17F / IL-24 stimulates PBMC and T-cell proliferation and Inhibits angiogenesis. Defects in IL17F are the cause of familial candidiasis type 6 (CANDF6).

IL-17F Recombinant Protein

11-226 0.1 mg
EUR 595.25
Description: Interleukin-17F (IL17F) is also known as Interleukin-24 (IL24), Cytokine ML-1, is a secreted disulfide-linked homodimer which belongs to the IL-17 family. There are at least six members of the IL-17 family in humans and in mice: IL-17A, IL-17B, IL-17C, IL-17D, IL-17E (also called IL-25) and IL-17F (also called IL-24). IL-17 represents a family of structurally related cytokines that share a highly conserved C-terminal region but differ from one another in their N-terminal regions and in their distinct biological roles. IL-17F / IL-24 is expressed in activated, but not resting, CD4+ T-cells and activated monocytes. IL17F / Interleukin-24 stimulates the production of other cytokines such as IL-6, IL-8 and granulocyte colony-stimulating factor, and can regulate cartilage matrix turnover. IL17F / IL-24 stimulates PBMC and T-cell proliferation and Inhibits angiogenesis. Defects in IL17F are the cause of familial candidiasis type 6 (CANDF6).

IL-17F Recombinant Protein

11-227 0.1 mg
EUR 595.25
Description: Interleukin-17F (IL17F) is also known as Interleukin-24 (IL24), Cytokine ML-1, is a secreted disulfide-linked homodimer which belongs to the IL-17 family. There are at least six members of the IL-17 family in humans and in mice: IL-17A, IL-17B, IL-17C, IL-17D, IL-17E (also called IL-25) and IL-17F (also called IL-24). IL-17 represents a family of structurally related cytokines that share a highly conserved C-terminal region but differ from one another in their N-terminal regions and in their distinct biological roles. IL-17F / IL-24 is expressed in activated, but not resting, CD4+ T-cells and activated monocytes. IL17F / Interleukin-24 stimulates the production of other cytokines such as IL-6, IL-8 and granulocyte colony-stimulating factor, and can regulate cartilage matrix turnover. IL17F / IL-24 stimulates PBMC and T-cell proliferation and Inhibits angiogenesis. Defects in IL17F are the cause of familial candidiasis type 6 (CANDF6).

IL-2 Recombinant Protein

11-249 0.1 mg
EUR 542.75
Description: Interleukin-2 (IL-2) is an interleukin, a type of cytokine immune system signaling molecule, which is a leukocytotrophic hormone that is instrumental in the body's natural response to microbial infection and in discriminating between foreign (non-self) and self. IL-2 mediates its effects by binding to IL-2 receptors, which are expressed by lymphocytes, the cells that are responsible for immunity. Mature human IL-2 shares 56% and 66% aa sequence identity with mouse and rat IL-2, respectively. Human and mouse IL-2 exhibit crossspecies activity. The receptor for IL-2 consists of three subunits that are present on the cell surface in varying preformed complexes. IL-2 is also necessary during T cell development in the thymus for the maturation of a unique subset of T cells that are termed regulatory T cells (T-regs). After exiting from the thymus, T-Regs function to prevent other T cells from recognizing and reacting against "self antigens", which could result in "autoimmunity". T-Regs do so by preventing the responding cells from producing IL-2. Thus, IL-2 is required to discriminate between self and non-self, another one of the unique characteristics of the immune system.

IL-13 Recombinant Protein

11-292 0.05 mg
EUR 595.25
Description: Interleukin 13 (IL13) is also known as ALRH, BHR1and P600, is a single-chain glycosylated polypeptide, and is a cytokine critical in regulating inflammatory and immune responses. IL13 is secreted by many cell types, but especially by T helper type 2 (Th2) cells. IL-13 induces its effects through a multi-subunit receptor that includes the alpha chain of the IL-4 receptor (IL-4Rα) and at least one of two known IL-13-specific binding chains. The functions of IL-13 overlap considerably with those of IL-4, especially with regard to changes induced on hematopoietic cells, but these effects are probably less important given the more potent role of IL-4. IL-13 induces matrix metalloproteinases (MMPs) as part of a mechanism that protects against excessive allergic inflammation that predisposes to asphyxiation. IL-13 induces many features of allergic lung disease, including airway hyperresponsiveness, goblet cell metaplasia and mucus hypersecretion, which all contribute to airway obstruction.

IL-13 Recombinant Protein

11-326 0.05 mg
EUR 684.5
Description: Interleukin 13 (IL13) is also known as ALRH, BHR1and P600, is a single-chain glycosylated polypeptide, and is a cytokine critical in regulating inflammatory and immune responses. IL13 is secreted by many cell types, but especially by T helper type 2 (Th2) cells. IL-13 induces its effects through a multi-subunit receptor that includes the alpha chain of the IL-4 receptor (IL-4Rα) and at least one of two known IL-13-specific binding chains. The functions of IL-13 overlap considerably with those of IL-4, especially with regard to changes induced on hematopoietic cells, but these effects are probably less important given the more potent role of IL-4. IL-13 induces matrix metalloproteinases (MMPs) as part of a mechanism that protects against excessive allergic inflammation that predisposes to asphyxiation. IL-13 induces many features of allergic lung disease, including airway hyperresponsiveness, goblet cell metaplasia and mucus hypersecretion, which all contribute to airway obstruction.

IL-15 Recombinant Protein

11-331 0.05 mg
EUR 595.25
Description: Interleukin 15 is also known as IL15, IL-15, and is a cytokine with structural similarity to IL-2. Like IL-2, IL-15 binds to and signals through the IL-2/IL-15 beta chain (CD122) and the common gamma chain (gamma-C, CD132). IL-15 is secreted by mononuclear phagocytes (and some other cells) following infection by virus(es). This cytokine induces cell proliferation of natural killer cells; cells of the innate immune system whose principal role is to kill virally infected cells. Interleukin 15 (IL-15) regulates T and natural killer (NK) cell activation and proliferation. Survival signals that maintain memory T cells in the absence of antigen are provided by IL-15. This cytokine is also implicated in NK cell development. In rodent lymphocytes, IL-15 prevents apoptosis by inducing an apoptosis inhibitor, BCL2L1/BCL-x(L). IL-15 has been shown to enhance the anti-tumor immunity of CD8+ T cells in pre-clinical models. A phase I clinical trial to evaluate the safety, dosing, and anti-tumor efficacy of IL-15 in patients with metastatic melanoma and renal cell carcinoma (kidney cancer) has begun to enroll patients at the National Institutes of Health.

IL-33 Recombinant Protein

11-340 0.05 mg
EUR 595.25
Description: Interleukin 33 (IL33) is known as C9orf26, DKFZp586H0523, DVS27, NF-HEV, NFEHEV, RP11-575C20.2,and is a cytokine belonging to the IL-1 superfamily. IL-33 induces helper T cells, mast cells, eosinophils and basophils to produce type 2 cytokines. IL-33 mediates its biological effects by interacting with the receptors ST2 (aka IL1RL1) and IL-1 Receptor Accessory Protein (IL1RAP), activating intracellular molecules in the NF-κB and MAP kinase signaling pathways that drive production of type 2 cytokines (e.g. IL-5 and IL-13) from polarized Th2 cells. In vivo, IL-33 induces the expression of IL-4, IL-5, and IL-13 and leads to severe pathological changes in mucosal organs.

IL-5 Recombinant Protein

11-348 0.05 mg
EUR 595.25
Description: Interleukin 5 (IL5) is an interleukin produced by type-2 T helper cells and mast cells. IL-5 is a 115-amino acid (in human, 133 in the mouse) -long TH2 cytokine that is part of the hematopoietic family. Unlike other members of this cytokine family (namely interleukin 3 and GM-CSF), this glycoprotein in its active form is a homodimer. Interleukin-5 has long been associated with the cause of several allergic diseases including allergic rhinitis and asthma, wherein a large increase in the number of circulating, airway tissue, and induced sputum eosinophils have been observed. Given the high concordance of eosinophils and, in particular, allergic asthma pathology, it has been widely speculated that eosinophils have an important role in the pathology of this disease. Drugs that target IL-5 are mepolizumab and reslizumab.

IL-15 Recombinant Protein

11-386 0.05 mg
EUR 710.75
Description: Interleukin 15 is also known as IL15, IL-15, and is a cytokine with structural similarity to IL-2. Like IL-2, IL-15 binds to and signals through the IL-2/IL-15 beta chain (CD122) and the common gamma chain (gamma-C, CD132). IL-15 is secreted by mononuclear phagocytes (and some other cells) following infection by virus(es). This cytokine induces cell proliferation of natural killer cells; cells of the innate immune system whose principal role is to kill virally infected cells. Interleukin 15 (IL-15) regulates T and natural killer (NK) cell activation and proliferation. Survival signals that maintain memory T cells in the absence of antigen are provided by IL-15. This cytokine is also implicated in NK cell development. In rodent lymphocytes, IL-15 prevents apoptosis by inducing an apoptosis inhibitor, BCL2L1/BCL-x(L). IL-15 has been shown to enhance the anti-tumor immunity of CD8+ T cells in pre-clinical models. A phase I clinical trial to evaluate the safety, dosing, and anti-tumor efficacy of IL-15 in patients with metastatic melanoma and renal cell carcinoma (kidney cancer) has begun to enroll patients at the National Institutes of Health.

IL-22 Recombinant Protein

11-396 0.05 mg
EUR 595.25
Description: Interleukin-22 (IL22) is also known as cytokine Zcyto18, IL-10-related T-cell-derived-inducible factor (IL-TIF), which is belongs to the IL-10 family or IL-10 superfamily (including IL-19, IL-20, IL-24, and IL-26), a class of potent mediators of cellular inflammatory responses. IL-22 is produced by activated DC and T cells and initiates innate immune responses against bacterial pathogens especially in epithelial cells such as respiratory and gut epithelial cells. IL-22 biological activity is initiated by binding to a cell-surface complex composed of IL-22R1 and IL-10R2 receptor chains and further regulated by interactions with a soluble binding protein IL-22BP. IL-22 also promotes hepatocyte survival in the liver and epithelial cells in the lung and gut similar to IL-10.

IL-21 Recombinant Protein

11-420 0.1 mg
EUR 595.25
Description: Interleukin-21 (IL-21) is a secreted protein which belongs to the IL-15 / IL-21 family. Interleukin-21 / IL-21 belongs to a family of cytokines that bind to a composite receptor consisting of a private receptor (IL21R) and the common cytokine receptor gamma chain (gamma(C)). Interleukin-21 / IL-21 impacts a number of cell types, including CD8+ memory T cells, NK cells and subsets of CD4 memory T cells. The IL-21R is widely distributed on lympho-haematopoietic cells. IL-21 is a pleiotropic cytokine produced by CD4+ T cells in response to antigenic stimulation. Its action generally enhances antigen-specific responses of immune cells. IL-21 promotes the anti-tumor activity of CD8+ T-cells and NK cells. IL-21 exerts its effect through binding to a specific type I cytokine receptor, IL-21R, which also contains the γ chain (γc) found in other cytokine receptors including IL-2, IL-4, IL-7, IL-9 and IL-15. The IL-21/IL-21R interaction triggers a cascade of events which includes activation of the tyrosine kinases JAK1 and JAK3, followed by activation of the transcription factors STAT1 and STAT3.

IL-11 Interleukin-11 Human Recombinant Protein

PROTP20809-1 Regular: 10ug
EUR 317
Description: Interleukin-11 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 179 amino acids and having a molecular mass of 19256.29 Dalton. ;The IL-11 is purified by proprietary chromatographic techniques.

IL-11 Interleukin-11 Mouse Recombinant Protein

PROTP47873 Regular: 10ug
EUR 317
Description: Interleukin-11 Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 179 amino acids and having a molecular mass of 19.1kDa. ;The Mouse IL-11 is purified by proprietary chromatographic techniques.

IL-1 Rrp2 / IL-1 R6 Recombinant Protein

11-170 0.1 mg
EUR 542.75
Description: The Interleukin 1 receptor family (IL-1 R) comprises at least eleven members including IL-1 RI (IL-1 R1), IL-1 RII (IL-1 R2), IL-1 RAcP (IL‑1 R3), ST2 (T1/IL-1 R4), IL-18 Ra (IL-1 Rrp/IL-1 R5), IL-1 Rrp2 (IL-1 RL2/IL-1 R6), IL-18 Rb (AcPL/IL-1 R7), IL-1RAPL‑1 (TIGIRR‑2/IL‑1 R8), and TIGIRR-1 (IL-1 R9). All family members possess three immunoglobulin (Ig)-like domains in their extracellular region. Most members also have an intracellular TIR (Toll-like receptor/IL-1 receptor signaling) domain that is also conserved in the Toll-like receptor family. Related proteins, SIGIRR (single Ig domain-containing IL-1 R-related molecule) and IL-18BP, differ from the other members by having only one Ig domain.

IL-1 Rrp2 / IL-1 R6 Recombinant Protein

11-437 0.1 mg
EUR 542.75
Description: The Interleukin 1 receptor family (IL-1 R) comprises at least eleven members including IL-1 RI (IL-1 R1), IL-1 RII (IL-1 R2), IL-1 RAcP (IL‑1 R3), ST2 (T1/IL-1 R4), IL-18 Ra (IL-1 Rrp/IL-1 R5), IL-1 Rrp2 (IL-1 RL2/IL-1 R6), IL-18 Rb (AcPL/IL-1 R7), IL-1RAPL‑1 (TIGIRR‑2/IL‑1 R8), and TIGIRR-1 (IL-1 R9). All family members possess three immunoglobulin (Ig)-like domains in their extracellular region. Most members also have an intracellular TIR (Toll-like receptor/IL-1 receptor signaling) domain that is also conserved in the Toll-like receptor family. Related proteins, SIGIRR (single Ig domain-containing IL-1 R-related molecule) and IL-18BP, differ from the other members by having only one Ig domain.

IL-1 Rrp2 / IL-1 R6 Recombinant Protein

11-448 0.1 mg
EUR 542.75
Description: The Interleukin 1 receptor family (IL-1 R) comprises at least eleven members including IL-1 RI (IL-1 R1), IL-1 RII (IL-1 R2), IL-1 RAcP (IL‑1 R3), ST2 (T1/IL-1 R4), IL-18 Ra (IL-1 Rrp/IL-1 R5), IL-1 Rrp2 (IL-1 RL2/IL-1 R6), IL-18 Rb (AcPL/IL-1 R7), IL-1RAPL‑1 (TIGIRR‑2/IL‑1 R8), and TIGIRR-1 (IL-1 R9). All family members possess three immunoglobulin (Ig)-like domains in their extracellular region. Most members also have an intracellular TIR (Toll-like receptor/IL-1 receptor signaling) domain that is also conserved in the Toll-like receptor family. Related proteins, SIGIRR (single Ig domain-containing IL-1 R-related molecule) and IL-18BP, differ from the other members by having only one Ig domain.

Recombinant Human IL-11 Protein

RP00050 5 μg
EUR 221

Recombinant Human IL-11 Protein

RP00474 10 μg
EUR 221

Recombinant Human IL-11 Protein

PROTP20809-2 10ug
EUR 317
Description: IL-11 is a multifunctional cytokine produced by stromal cells such as fibroblasts, epithelial cells and osteoclasts. It is expressed in a wide variety of tissues including thymus, lung, bone, connective tissue and central nervous system. IL-11 plays an important regulatory role in hematopoiesis by stimulating growth of myeloid, erythroid and megakaryocyte progenitor cells. It also regulates bone metabolism, inhibits production of proinflammatory cytokines and protects against gastromucosal injury. Recombinant Human IL-11 is a 19.3 kDa protein consisting of 179 amino acid residues.

Recombinant Murine IL-11 Protein

PROTP47873-1 10ug
EUR 317
Description: IL-11 is a multifunctional cytokine produced by stromal cells such as fibroblasts, epithelial cells and osteoclasts. It is expressed in a wide variety of tissues including thymus, lung, bone, connective tissue and central nervous system. IL-11 plays an important regulatory role in hematopoiesis by stimulating growth of myeloid, erythroid and megakaryocyte progenitor cells. It also regulates bone metabolism, inhibits production of proinflammatory cytokines and protects against gastromucosal injury. Recombinant Murine IL-11 is a 19.1 kDa protein consisting of 179 amino acid residues.

Swine IL-8 Recombinant Protein

R00423-11 5ug/vial
EUR 259
Description: Interleukin-8 (IL-8), also known as CXCL8, is an ELR-positive CXC family member chemokine produced by macrophages and other cell types such as epithelial cells. ELR-positive CXC chemokines such as IL-8 specifically induce the migration of neutrophils, and interact with chemokine receptors CXCR1 and CXCR2. Swine IL-8 Recombinant Protein is purified interleukin-8 produced in yeast.

IL-31 RA Recombinant Protein

11-125 0.1 mg
EUR 595.25
Description: Interleukin-31 receptor subunit alpha is a protein that in humans is encoded by the IL31RA gene, also known as IL-31 receptor subunit alpha, IL-31RA, GLM-R, Gp130-like receptor, CRL3, GPL. Oncostatin M receptor (OSMR) and IL31RA form the heterodimeric receptor through which IL31 signals. IL31RA is a strong activator of STAT3 and STAT5, whereas STAT1 is only marginally tyrosine-phosphorylated. dditionally, demonstrate Jak1 binding to GPL and its activation in heteromeric complexes with the OSMRbeta but also in a homomeric receptor complex.

IL-8 / CXCL8 Recombinant Protein

11-160 0.1 mg
EUR 595.25
Description: Interleukin 8 (IL8 or chemokine (C-X-C motif) ligand 8, CXCL8) is a chemokine produced by macrophages and other cell types such as epithelial cells, airway smooth muscle cells and endothelial cells. There are many receptors on the surface membrane capable of binding IL-8, the most frequently studied types are the G protein-coupled serpentine receptors CXCR1 and CXCR2. Expression and affinity for IL-8 differs between the two receptors (CXCR1 > CXCR2). IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively.

Biotinylated IL-22 Recombinant Protein

11-174 0.025 mg
EUR 595.25
Description: Interleukin-22 (IL22) is also known as cytokine Zcyto18, IL-10-related T-cell-derived-inducible factor (IL-TIF), which is belongs to the IL-10 family or IL-10 superfamily (including IL-19, IL-20, IL-24, and IL-26), a class of potent mediators of cellular inflammatory responses. IL-22 is produced by activated DC and T cells and initiates innate immune responses against bacterial pathogens especially in epithelial cells such as respiratory and gut epithelial cells. IL-22 biological activity is initiated by binding to a cell-surface complex composed of IL-22R1 and IL-10R2 receptor chains and further regulated by interactions with a soluble binding protein IL-22BP. IL-22 also promotes hepatocyte survival in the liver and epithelial cells in the lung and gut similar to IL-10.

IL-8 / CXCL8 Recombinant Protein

11-219 0.1 mg
EUR 595.25
Description: Interleukin 8 (IL8 or chemokine (C-X-C motif) ligand 8, CXCL8) is a chemokine produced by macrophages and other cell types such as epithelial cells, airway smooth muscle cells and endothelial cells. There are many receptors on the surface membrane capable of binding IL-8, the most frequently studied types are the G protein-coupled serpentine receptors CXCR1 and CXCR2. Expression and affinity for IL-8 differs between the two receptors (CXCR1 > CXCR2). IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively.

IL-31 RA Recombinant Protein

11-354 0.1 mg
EUR 595.25
Description: Interleukin-31 receptor subunit alpha is a protein that in humans is encoded by the IL31RA gene, also known as IL-31 receptor subunit alpha, IL-31RA, GLM-R, Gp130-like receptor, CRL3, GPL. Oncostatin M receptor (OSMR) and IL31RA form the heterodimeric receptor through which IL31 signals. IL31RA is a strong activator of STAT3 and STAT5, whereas STAT1 is only marginally tyrosine-phosphorylated. dditionally, demonstrate Jak1 binding to GPL and its activation in heteromeric complexes with the OSMRbeta but also in a homomeric receptor complex.

IL-8 / CXCL8 Recombinant Protein

11-355 0.1 mg
EUR 595.25
Description: Interleukin 8 (IL8 or chemokine (C-X-C motif) ligand 8, CXCL8) is a chemokine produced by macrophages and other cell types such as epithelial cells, airway smooth muscle cells and endothelial cells. There are many receptors on the surface membrane capable of binding IL-8, the most frequently studied types are the G protein-coupled serpentine receptors CXCR1 and CXCR2. Expression and affinity for IL-8 differs between the two receptors (CXCR1 > CXCR2). IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively.

IL-23 R Recombinant Protein

11-366 0.1 mg
EUR 595.25
Description: Interleukin 23 receptor (IL-23R) is a type I cytokine receptor, and IL-23R pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. Also, IL-23R associates constitutively with Janus kinase 2 (JAK2), and binds to transcription activator STAT3 in a ligand-dependent manner. Furthermore, IL-23R mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. As for IL-23, it may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis.

IL-23 R Recombinant Protein

11-428 0.1 mg
EUR 595.25
Description: Interleukin 23 receptor (IL-23R) is a type I cytokine receptor, and IL-23R pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. Also, IL-23R associates constitutively with Janus kinase 2 (JAK2), and binds to transcription activator STAT3 in a ligand-dependent manner. Furthermore, IL-23R mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. As for IL-23, it may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis.

Recombinant Human Interleukin-11/IL-11

C006-10ug 10ug
EUR 202
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 2% Glycine, pH 7.2.

Recombinant Human Interleukin-11/IL-11

C006-1mg 1mg
EUR 1836
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 2% Glycine, pH 7.2.

Recombinant Human Interleukin-11/IL-11

C006-500ug 500ug
EUR 1298
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 2% Glycine, pH 7.2.

Recombinant Human Interleukin-11/IL-11

C006-50ug 50ug
EUR 496
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 2% Glycine, pH 7.2.

IL-11, human recombinant

4158-10
EUR 283

IL-11, human recombinant

4158-1000
EUR 6314

IL-11, human recombinant

4158-50
EUR 827

IL-11, murine recombinant

4159-10
EUR 327

IL-11, murine recombinant

4159-1000
EUR 7771

IL-11, murine recombinant

4159-50
EUR 936

IL-11 Interleukin-11 Human Recombinant Protein, Pichia

PROTP20809 Regular: 10ug
EUR 317
Description: IL11 Human Recombinant produced in Pichia Pastoris is a single, non-glycosylated, Polypeptide chain containing 177 amino acids (it differs from the 178 amino acid length of the native IL11 only in lack of the N-terminal praline residue) and having a molecular mass of 19kDa.;The IL11 is purified by proprietary chromatographic techniques.

IL-1 Rrp2 / IL-1 R6 (C154S, C262S) Recombinant Protein

11-120 0.1 mg
EUR 542.75
Description: The Interleukin 1 receptor family (IL-1 R) comprises at least eleven members including IL-1 RI (IL-1 R1), IL-1 RII (IL-1 R2), IL-1 RAcP (IL‑1 R3), ST2 (T1/IL-1 R4), IL-18 Ra (IL-1 Rrp/IL-1 R5), IL-1 Rrp2 (IL-1 RL2/IL-1 R6), IL-18 Rb (AcPL/IL-1 R7), IL-1RAPL‑1 (TIGIRR‑2/IL‑1 R8), and TIGIRR-1 (IL-1 R9). All family members possess three immunoglobulin (Ig)-like domains in their extracellular region. Most members also have an intracellular TIR (Toll-like receptor/IL-1 receptor signaling) domain that is also conserved in the Toll-like receptor family. Related proteins, SIGIRR (single Ig domain-containing IL-1 R-related molecule) and IL-18BP, differ from the other members by having only one Ig domain.

IL-11

E21-006 10ug
EUR 343

Turkey IL-1 beta Recombinant Protein

R00101-11 5ug/vial
EUR 259
Description: IL-1 beta (IL-1β) is a member of the interleukin 1 family of cytokines. The IL-1 beta cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. Turkey IL-1 beta Recombinant Protein is purified interleukin-1 beta cytokine produced in yeast.

IL-11 Recombinant Protein (Animal Free)

40-730 2 ug
EUR 269.75
Description: IL-11 is a multifunctional cytokine produced by stromal cells, such as fibroblasts, epithelial cells and osteoclasts. It is expressed in a wide variety of tissues, including thymus, lung, bone, connective tissue and central nervous system. IL-11 plays an important regulatory role in hematopoiesis by stimulating growth of myeloid, erythroid and megakaryocyte progenitor cells. It also regulates bone metabolism, inhibits production of proinflammatory cytokines, and protects against gastromucosal injury. Recombinant Human IL-11 is a 19.3 kDa protein consisting of 179 amino acid residues.

IL-11/ Rat IL- 11 ELISA Kit

ELA-E0057r 96 Tests
EUR 886

IL-17 RE (155-454) Recombinant Protein

11-285 0.1 mg
EUR 595.25
Description: Interleukin-17 receptor E (IL-17 RE) is an orphan receptor of the IL-17 receptor family, also known as UNQ3056, PRO9877, IL-17 Receptor E. IL-17RE is known to be expressed in the pancreas, brain, and prostate. IL-17RE is a receptor specific to IL-17C and has an essential role in host mucosal defense against infection. IL-17C functioned in a unique autocrine manner, binding to a receptor complex consisting of the receptors IL-17RA and IL-17RE, which was preferentially expressed on tissue epithelial cells. Some data identify IL-17RE as a receptor of IL-17C that regulates early innate immunity to intestinal pathogens.

IL-13 R alpha 2 Recombinant Protein

11-325 0.1 mg
EUR 542.75
Description: Interleukin-13 receptor subunit alpha-2 is also known as IL13Rα2, IL13Ra2 cluster of differentiation 213A2, CD213A2, CT19, IL-13R, IL13BP, and is a membrane bound protein that in humans is encoded by the IL13RA2 gene. IL13Rα2 is closely related to IL13Rα1, a subunit of the interleukin-13 receptor complex. This protein binds IL13 with high affinity, but lacks any significant cytoplasmic domain, and does not appear to function as a signal mediator. It is, however able to regulate the effects of both IL13 and IL4, despite the fact it is unable to bind directly to the latter. It is also reported to play a role in the internalization of IL13. IL13Rα2 is a component of the cell surface receptors, however, the majority exists in intracellular pools and in soluble form, and thus plays an opposite role as a potent IL13 antagonist compared with IL13Rα1. It also functions as an inhibitor of IL4-dependent pathway probably through the physical interaction between the short intracellular domain of and cytoplasmic domain of IL13Rα2 and the IL4Rα chain. In spite of the failed STAT signaling function, IL13Rα2 dose induce TGF-beta production and fibrosis. Additionally, IL13Rα2has been reported to be abundantly and specifically overexpressed in glioblastoma multiforme.

IL-5 R alpha / CD125 Recombinant Protein

11-347 0.05 mg
EUR 595.25
Description: Interleukin-5 receptor subunit alpha (IL5RA) is also known as IL-5 receptor subunit alpha, IL-5R subunit alpha and CD125,which is a single-pass type I membrane protein that belongs to the type I cytokine receptor family and type 5 subfamily.IL5R, a heterodimer of an alpha and a beta subunit, is expressed on eosinophils and basophils. IL5RA / CD125 is the receptor for interleukin-5 (IL5) and the alpha chain can bind to IL5. The WSXWS motif of IL5RA appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.The beta subunit of IL5R is common to the IL3, IL5 and GM-CSF receptors.

IL-2 R alpha / CD25 Recombinant Protein

11-351 0.1 mg
EUR 542.75
Description: Interleukin-2 receptor subunit alpha (IL2RA) is also known as IL-2R subunit alpha, IL-2-RA, IL2-RA, TAC antigen, p55, CD antigen CD25, is a type I transmembrane glycoprotein. IL2RA is expressed on activated T cells and regulatory T cells, and is capable of binding IL2 with low affinity by itself. However, a ligand-induced high affinity heterotrimeric receptor complex is produced when IL2RA is associated non-covelently with the IL2 receptor beta and gamma chain, and subsequently initiates the intacellular signal pathways such as MAPK or JAK/STAT. On dendritic cells (DC), CD25 has been previously regarded as an activation marker, while both murine and human DC can express CD25, they do not express the beta-chain of the IL-2 receptor, which is indispensable for the execution of IL-2 signaling.

IL-15 R alpha / CD215 Recombinant Protein

11-365 0.1 mg
EUR 542.75
Description: IL15R is a heterotrimer of IL15RA, IL2RB and IL2RG. IL-15RA, also known as CD215, IL-15 R alpha, is a widely expressed 60 kDa transmembrane glycoprotein. High-affinity receptor for interleukin-15. Can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. Expression of different isoforms may alter or interfere with signal transduction. An interleukin (IL)-15 superagonist/IL-15 receptor α fusion complex (IL-15SA/IL-15RA; ALT-803) activates the IL-15 receptor on CD8 T cells and NK cells, and has shown significant anti-tumor. Signal transduction involves SYK. Higher levels of soluble sIL-15RA form in comparison with membrane-bound forms is present in all brain structures.

IL-6 R alpha / CD126 Recombinant Protein

11-390 0.1 mg
EUR 595.25
Description: Interleukin 6 receptor (IL6R) is also known as CD126 (Cluster of Differentiation 126) , is a potent pleiotropic cytokine that regulates cell growth and differentiation of various tissues, and is known particularly for its role in the immune response and acute phase reactions. IL6R is a protein complex consisting of a IL-6 receptor subunit (IL6R) and interleukin 6 signal transducer Glycoprotein 130. IL6R also denotes the human gene encoding this subunit. Alternatively spliced transcript variants encoding distinct isoforms have been reported. IL6R subunit also shared by many other cytokines. The soluble form of IL6R arises from proteolytic cleavage of membrane-bound IL6Rα, and acts agonistically by making the IL6 ligand accessible to the signal transducer gp130. Dysregulated production of IL6 and IL6R are implicated in the pathogenesis of several inflammatory diseases and malignancies such as multiple myeloma, rheumatoid arthritis, or osteoporosis, and it has been reported that a humanized anti-IL6R monoclonal antibody is a promising agent applicable to the therapeutic approach for IL6 driven diseases. Interleukin-6 receptor has been shown to interact with Interleukin 6 and Ciliary neurotrophic factor.

IL-4 R alpha / CD124 Recombinant Protein

11-393 0.1 mg
EUR 595.25
Description: IL-4 R alpha is also known as IL4R, CD124, IL-4RA.This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE antibody production in B cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitis, asthma, or eczema. The binding of IL-4 or IL-13 to the IL-4 receptor on the surface of macrophages results in the alternative activation of those macrophages. Interleukin-4 receptor has been shown to interact with SHC1.

IL-7 R alpha / CD127 Recombinant Protein

11-538 0.1 mg
EUR 569
Description: Interleukin-7 receptor subunit alpha (IL7Ra) is also known as CD antigen CD127, which belongs to the type I cytokine receptor family and type 4 subfamily. IL7Ra /CD127 contains 1 fibronectin type-III domain. IL7Ra /CD127 is expressed on various cell types, including naive and memory T cells and many others. IL7Ra /CD127 is receptor for interleukin-7 and also acts as a receptor for thymic stromal lymphopoietin (TSLP). The IL7 receptor is a heterodimer of IL7R and IL2RG. The TSLP receptor is a heterodimer of CRLF2 and IL7R.

Recombinant Mouse Interleukin-11/IL-11 (C-Fc)

CJ59-10ug 10ug
EUR 156
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Recombinant Mouse Interleukin-11/IL-11 (C-Fc)

CJ59-1mg 1mg
EUR 2283
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Recombinant Mouse Interleukin-11/IL-11 (C-Fc)

CJ59-500ug 500ug
EUR 1613
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Recombinant Mouse Interleukin-11/IL-11 (C-Fc)

CJ59-50ug 50ug
EUR 369
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

IL-11, Interleukin-11, human

RC212-22 2ug
EUR 104.38

IL-12 R beta 1 / CD212 Recombinant Protein

11-342 0.1 mg
EUR 542.75
Description: The human IL-12 R subunit is a member of the cytokine receptor superfamily and the functional high-affinity IL-12R is composed of at least two beta-type cytokine receptor subunits, each independently exhibiting a low affinity for IL-12. IL-12 R beta 1 (Interleukin-12 receptor subunit beta-1) is also known as IL-12RB1, CD212. Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a functional, high affinity receptor for IL12. Associates also with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade.

IL-12 R beta 1 / CD212 Recombinant Protein

11-385 0.1 mg
EUR 516.5
Description: The human IL-12 R subunit is a member of the cytokine receptor superfamily and the functional high-affinity IL-12R is composed of at least two beta-type cytokine receptor subunits, each independently exhibiting a low affinity for IL-12. IL-12 R beta 1 (Interleukin-12 receptor subunit beta-1) is also known as IL-12RB1, CD212. Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a functional, high affinity receptor for IL12. Associates also with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade.

Recombinant Human IL-11/ interleukin 11 Protein, Untagged, E.coli-100ug

QP10319-ec-100ug 100ug
EUR 1678

Recombinant Human IL-11/ interleukin 11 Protein, Untagged, E.coli-10ug

QP10319-ec-10ug 10ug
EUR 290

Recombinant Human IL-11/ interleukin 11 Protein, Untagged, E.coli-250ug

QP10319-ec-250ug 250ug
EUR 2956

Recombinant Human IL-11/ interleukin 11 Protein, Untagged, E.coli-2ug

QP10319-ec-2ug 2ug
EUR 154

Recombinant Mouse IL-11/ interleukin 11 Protein, Untagged, E.coli-100ug

QP10459-ec-100ug 100ug
EUR 1678

Recombinant Mouse IL-11/ interleukin 11 Protein, Untagged, E.coli-10ug

QP10459-ec-10ug 10ug
EUR 290

Recombinant Mouse IL-11/ interleukin 11 Protein, Untagged, E.coli-250ug

QP10459-ec-250ug 250ug
EUR 2956

Recombinant Mouse IL-11/ interleukin 11 Protein, Untagged, E.coli-2ug

QP10459-ec-2ug 2ug
EUR 154

Recombinant Human IL-11/ interleukin 11 Protein, Untagged, E.coli-1mg

QP5387-1mg 1mg
EUR 4952

Recombinant Human IL-11/ interleukin 11 Protein, Untagged, E.coli-500ug

QP5387-500ug 500ug
EUR 3038

Recombinant Mouse IL-11/ interleukin 11 Protein, Untagged, E.coli-1mg

QP5472-1mg 1mg
EUR 4952

Recombinant Mouse IL-11/ interleukin 11 Protein, Untagged, E.coli-500ug

QP5472-500ug 500ug
EUR 3038

IL-11, Human

HY-P7031 10ug
EUR 268

IL 11 Antibody

abx216277-100ug 100 ug
EUR 439

IL 11 Antibody

AF5211 200ul
EUR 304
Description: IL 11 Antibody detects endogenous levels of total IL 11.

rHu IL-11

AK8305-0002 2µg Ask for price

rHu IL-11

AK8305-0005 1mg Ask for price

rHu IL-11

AK8305-0010 10µg Ask for price

rHu IL-11

AK8305-0100 100µg Ask for price

IL 11 Antibody

ABF5211 100 ug
EUR 438

IL-11 Peptide

8453P 0.05 mg
EUR 164.75
Description: IL-11 Peptide

IL-11 Antibody

8453-002mg 0.02 mg
EUR 171.82
Description: Interleukin 11 is a pleiotropic cytokine that has multiple effects on both hematopoietic and nonhematopoietic cells. Many of the biological effects described for IL-11 overlap those for IL-6 (1). It directly stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production (2). IL-11 promotes the proliferation of hepatocytes in response to liver damage. IL-11 binds to its receptor formed by IL6ST and either IL11RA1 or IL11RA2 (3). Clinically it is used to prevent severe thrombocytopenia and the reduction of the need for platelet transfusion following myelo-suppressive chemotherapy (4).

IL-11 Antibody

8453-01mg 0.1 mg
EUR 436.42
Description: Interleukin 11 is a pleiotropic cytokine that has multiple effects on both hematopoietic and nonhematopoietic cells. Many of the biological effects described for IL-11 overlap those for IL-6 (1). It directly stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production (2). IL-11 promotes the proliferation of hepatocytes in response to liver damage. IL-11 binds to its receptor formed by IL6ST and either IL11RA1 or IL11RA2 (3). Clinically it is used to prevent severe thrombocytopenia and the reduction of the need for platelet transfusion following myelo-suppressive chemotherapy (4).

IL-11, Interleukin-11, murine (mouse)

RC232-22 2ug
EUR 104.38

IL-11 (Interleukin 11) GMP, CF

PR15133CF 50 ug
EUR 3755

IL-11 Polyclonal Antibody

ES5892-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against IL-11 from Human/Mouse/Rat. This antibody is tested and validated for IHC, WB, ELISA

IL-11 Polyclonal Antibody

ES5892-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against IL-11 from Human/Mouse/Rat. This antibody is tested and validated for IHC, WB, ELISA

IL-11 Polyclonal Antibody

ABP54893-003ml 0.03ml
EUR 158
Description: A polyclonal antibody for detection of IL-11 from Human, Mouse, Rat. This IL-11 antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the N-terminal region of human IL-11

The compound includes a nicotinonitrile scaffold with micromolar affinity and efficiency for the cytokine, and disrupts sort II IL-Four signaling in cells. Small-molecule inhibitors of those necessary cell-signaling proteins have implications for numer-ous immune-related problems and informs future drug discovery and design efforts for these chal-lenging protein targets.

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