You are currently viewing Activated microglia-derived macrophage-like cells exacerbate brain edema after ischemic stroke correlate with astrocytic expression of aquaporin-<em>4</em> and <em>interleukin</em>-1 alpha release

Activated microglia-derived macrophage-like cells exacerbate brain edema after ischemic stroke correlate with astrocytic expression of aquaporin-4 and interleukin-1 alpha release

Mind edema following mind infarction impacts mobility and mortality. The mechanisms underlying this course of stay to be elucidated. Animal research have proven that aquaporin-4 (AQP4) expression in astrocytes will increase after stroke, and its deletion considerably reduces mind swelling. Just lately, two sorts of cells, resident microglia-derived macrophage-like cells (MG-MΦ) and bone marrow-derived macrophages (BM-MΦ), have been reported to build up within the ischemic core and stimulate adjoining astrocytes.

Subsequently, we hypothesized that these cells play essential roles within the expression of AQP4 and finally result in exacerbated mind edema. To confirm this speculation, we investigated the position of MG- or BM-MΦ in mind edema utilizing a rat mannequin of transient center cerebral artery occlusion and rat astrocyte main cultures. AQP4 expression considerably elevated within the peri-infarct tissue at 3-7 days post-reperfusion (dpr) and within the core tissue at 5 and seven dpr, which synchronized with the expression of Iba1, Il1a, Tnf, and C1qa mRNA. Interleukin (IL)-1α remedy or coculture with MG- and BM-MΦ elevated AQP4 expression in astrocytes, whereas an IL-1 receptor sort I antagonist diminished these results.

Moreover, aggravated animals exhibited excessive expression of Aqp4 and Il1a mRNA within the ischemic core at 7 dpr, which led to the exacerbation of mind edema. MG-MΦ signature genes have been extremely expressed within the ischemic core in aggravated rats, whereas BM-MΦ signature genes have been weakly expressed. These findings counsel that IL-1α produced by MG-MΦ induces astrocytic AQP4 expression within the peri-infarct and ischemic core tissues, thereby exacerbating mind edema. Subsequently, the regulation of MG-MΦ might forestall the exacerbation of mind edema.

<i>Porphyromonas gingivalis</i>-Induced NLRP3 Inflammasome Activation and Its Downstream <em>Interleukin</em>-1β Launch Rely on Caspase-<em>4</em>

Oral commensals contribute to microbe-host symbiosis in periodontal homeostasis, and Porphyromonas gingivalis (P. gingivalis) because the keystone pathogen critically accounts for the shift of symbiosis to dysbiosis and periodontal destruction. Nucleotide-binding oligomerization area (NOD)-like receptor (NLR) household pyrin area containing 3 (NLRP3) inflammasome-mediated interleukin-1β (IL-1β) is considerably concerned in periodontal illnesses, and notably P. gingivalis permits to modulate the induction and expression of NLRP3. Whereas, the precise mechanism by which NLRP3 inflammasome is regulated in response to commensal and pathogenic micro organism stays unclear.

Strategies: To look at the expression of IL-1β and NLRPs inflammasome in tissues with extreme continual periodontitis, and additional examine how Caspase-4-dependent non-canonical NLRP3 inflammasome pathways functioned throughout the interactions of Streptococcus mitis (S. mitis) and P. gingivalis with human THP-1 cells.

Outcomes: IL-1β and NLRP3, NLRP6, NLRP12, and absent in melanoma 2 (AIM2) inflammasomes are extremely expressed in gingival tissues with extreme continual periodontitis. In human THP-1 cells, P. gingivalis prompts the synthesis and secretion of IL-1β to greater ranges than S. mitis. Importantly, NLRP3-, Caspase-1-, and Caspase-4-siRNA knockdown THP-1 cells handled with P. gingivalis exhibited a decrease expression stage of IL-1β as in comparison with the management cells.

As well as, silencing of both CASP4 or CASP1 can result in a concurrent or reciprocal lower within the expression of the opposite. Of word, the IL-1β induction shouldn’t be affected within the S. mitis-treated THP-1 cells with the silence of NLRP3, Caspase-1, and Caspase-Four genes.

Conclusion: NLRP3/Caspase-Four and NLRP3/Caspase-1 dependent IL-1β manufacturing might crucially contribute to the dysregulated immuno-inflammatory response in periodontal pathogenesis.

Inhibition of Tumor Development towards Chemoresistant Cholangiocarcinoma by a Professional-apoptotic Peptide Focusing on <em>Interleukin</em>-<em>4</em> Receptor

Cholangiocarcinoma (CCA) has a poor prognosis and excessive chemoresistance. Interleukin-Four receptor (IL-4R) is overexpressed in a number of most cancers cells and performs a vital position in tumor development and drug resistance. IL4RPep-1, an IL-4R-binding peptide, has been recognized by phage show and used for tumor-targeting. On this research, we exploited IL4RPep-1 to information the tumor-specific supply of a pro-apoptotic peptide to chemoresistant CCA, thereby inhibiting tumor progress.

Activated microglia-derived macrophage-like cells exacerbate brain edema after ischemic stroke correlate with astrocytic expression of aquaporin-<em>4</em> and <em>interleukin</em>-1 alpha release

Immunohistochemistry of human main CCA tissues confirmed that IL-4R ranges have been upregulated in reasonably to poorly differentiated varieties, and better ranges of IL-4R are correlated with decrease survival price in sufferers with CCA. IL4RPep-1 was noticed to preferentially bind with excessive IL-4R-expressing KKU-213 human CCA cells, whereas it barely sure to low IL-4R-expressing KKU-055 cells.

A hybrid of IL4RPep-1 and a pro-apoptotic peptide (KLAKLAK)2 (named IL4RPep-1-KLA) induced cytotoxicity and apoptosis in KKU-213 cells and elevated these ranges induced by 5-fluorouracil (5-FU). IL4RPep-1-KLA was internalized into the cells and co-localized with mitochondria. Complete-body fluorescence imaging and immunohistochemical evaluation of tumor tissues confirmed the homing of IL4RPep-1-KLA in addition to IL4RPep-1 to KKU-213 tumor in mice.

Systemic administration of IL4RPep-1-KLA effectively inhibited KKU-213 tumor progress, whereas remedy with 5-FU alone didn’t considerably inhibit tumor progress in mice. No vital systemic unintended effects together with liver toxicity and immunotoxicity have been noticed in mice throughout the peptide therapies. These findings counsel that IL4RPep-1-KLA holds potential as a focused therapeutic agent towards chemoresistant CCA.

A Small-Molecule Inhibitor to the Cytokine <em>Interleukin</em>-<em>4</em>

Interleukin-4 (IL-4) is a multifunctional cytokine and an necessary regulator of irritation. When deregulated, IL-Four exercise is related to bronchial asthma, allergic irritation, and a number of sorts of most cancers. Whereas antibody-based inhibitors concentrating on the solu-ble cytokine have been evaluated clinically, they failed to realize their endpoints in trials.

Small-molecule inhibitors are a sexy various, however figuring out efficient chemotypes that inhibit the protein-protein interactions between cytokines and their receptors stays an lively space of analysis. Consequently, no small-molecule inhibitors to the sol-uble IL-Four cytokine have but been reported. Right here, we describe the primary IL-Four small-molecule inhibitor recognized and characterised by way of a mixture of binding-based approaches and cell-based exercise assays.

Recombinant Human IL-11 Protein

RP00474 10 μg
EUR 221

Recombinant Murine IL-11 Protein

PROTP47873-1 10ug
EUR 317
Description: IL-11 is a multifunctional cytokine produced by stromal cells such as fibroblasts, epithelial cells and osteoclasts. It is expressed in a wide variety of tissues including thymus, lung, bone, connective tissue and central nervous system. IL-11 plays an important regulatory role in hematopoiesis by stimulating growth of myeloid, erythroid and megakaryocyte progenitor cells. It also regulates bone metabolism, inhibits production of proinflammatory cytokines and protects against gastromucosal injury. Recombinant Murine IL-11 is a 19.1 kDa protein consisting of 179 amino acid residues.

Swine IL-8 Recombinant Protein

R00423-11 5ug/vial
EUR 259
Description: Interleukin-8 (IL-8), also known as CXCL8, is an ELR-positive CXC family member chemokine produced by macrophages and other cell types such as epithelial cells. ELR-positive CXC chemokines such as IL-8 specifically induce the migration of neutrophils, and interact with chemokine receptors CXCR1 and CXCR2. Swine IL-8 Recombinant Protein is purified interleukin-8 produced in yeast.

Recombinant Human Interleukin-11/IL-11

C006-10ug 10ug
EUR 202
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 2% Glycine, pH 7.2.

Recombinant Human Interleukin-11/IL-11

C006-1mg 1mg
EUR 1836
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 2% Glycine, pH 7.2.

Recombinant Human Interleukin-11/IL-11

C006-500ug 500ug
EUR 1298
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 2% Glycine, pH 7.2.

Recombinant Human Interleukin-11/IL-11

C006-50ug 50ug
EUR 496
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 2% Glycine, pH 7.2.

IL-11, human recombinant

4158-10
EUR 283

IL-11, human recombinant

4158-1000
EUR 6314

IL-11, human recombinant

4158-50
EUR 827

IL-11, murine recombinant

4159-10
EUR 327

IL-11, murine recombinant

4159-1000
EUR 7771

IL-11, murine recombinant

4159-50
EUR 936

IL-11 Interleukin-11 Human Recombinant Protein, Pichia

PROTP20809 Regular: 10ug
EUR 317
Description: IL11 Human Recombinant produced in Pichia Pastoris is a single, non-glycosylated, Polypeptide chain containing 177 amino acids (it differs from the 178 amino acid length of the native IL11 only in lack of the N-terminal praline residue) and having a molecular mass of 19kDa.;The IL11 is purified by proprietary chromatographic techniques.

Turkey IL-1 beta Recombinant Protein

R00101-11 5ug/vial
EUR 259
Description: IL-1 beta (IL-1β) is a member of the interleukin 1 family of cytokines. The IL-1 beta cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. Turkey IL-1 beta Recombinant Protein is purified interleukin-1 beta cytokine produced in yeast.

IL-11

E21-006 10ug
EUR 343

IL-11/ Rat IL- 11 ELISA Kit

ELA-E0057r 96 Tests
EUR 886

Recombinant Mouse Interleukin-11/IL-11 (C-Fc)

CJ59-10ug 10ug
EUR 156
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Recombinant Mouse Interleukin-11/IL-11 (C-Fc)

CJ59-1mg 1mg
EUR 2283
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Recombinant Mouse Interleukin-11/IL-11 (C-Fc)

CJ59-500ug 500ug
EUR 1613
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Recombinant Mouse Interleukin-11/IL-11 (C-Fc)

CJ59-50ug 50ug
EUR 369
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Recombinant Human IL-11/ interleukin 11 Protein, Untagged, E.coli-100ug

QP10319-ec-100ug 100ug
EUR 1678

Recombinant Human IL-11/ interleukin 11 Protein, Untagged, E.coli-10ug

QP10319-ec-10ug 10ug
EUR 290

Recombinant Human IL-11/ interleukin 11 Protein, Untagged, E.coli-250ug

QP10319-ec-250ug 250ug
EUR 2956

Recombinant Human IL-11/ interleukin 11 Protein, Untagged, E.coli-2ug

QP10319-ec-2ug 2ug
EUR 154

Recombinant Mouse IL-11/ interleukin 11 Protein, Untagged, E.coli-100ug

QP10459-ec-100ug 100ug
EUR 1678

Recombinant Mouse IL-11/ interleukin 11 Protein, Untagged, E.coli-10ug

QP10459-ec-10ug 10ug
EUR 290

Recombinant Mouse IL-11/ interleukin 11 Protein, Untagged, E.coli-250ug

QP10459-ec-250ug 250ug
EUR 2956

Recombinant Mouse IL-11/ interleukin 11 Protein, Untagged, E.coli-2ug

QP10459-ec-2ug 2ug
EUR 154

Recombinant Human IL-11/ interleukin 11 Protein, Untagged, E.coli-1mg

QP5387-1mg 1mg
EUR 4952

Recombinant Human IL-11/ interleukin 11 Protein, Untagged, E.coli-500ug

QP5387-500ug 500ug
EUR 3038

Recombinant Mouse IL-11/ interleukin 11 Protein, Untagged, E.coli-1mg

QP5472-1mg 1mg
EUR 4952

Recombinant Mouse IL-11/ interleukin 11 Protein, Untagged, E.coli-500ug

QP5472-500ug 500ug
EUR 3038

IL-11, Interleukin-11, human

RC212-22 2ug
EUR 104.38
  • Product category: Proteins/Recombinant Proteins/Cytokines

rHu IL-11

AK8305-0002 2µg Ask for price

rHu IL-11

AK8305-0005 1mg Ask for price

rHu IL-11

AK8305-0010 10µg Ask for price

rHu IL-11

AK8305-0100 100µg Ask for price

IL 11 Antibody

AF5211 200ul
EUR 304
Description: IL 11 Antibody detects endogenous levels of total IL 11.

IL-11, Human

HY-P7031 10ug
EUR 268

IL 11 Antibody

ABF5211 100 ug
EUR 438

IL 11 Antibody

abx216277-100ug 100 ug
EUR 439
  • Shipped within 5-10 working days.

IL-11 (Interleukin 11) GMP, CF

PR15133CF 50 ug
EUR 3755

IL-11, Interleukin-11, murine (mouse)

RC232-22 2ug
EUR 104.38
  • Product category: Proteins/Recombinant Proteins/Cytokines

IL 11 Blocking Peptide

AF5211-BP 1mg
EUR 195

Polyclonal IL-11 Antibody

APR06928G 0.1 mg
EUR 659
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human IL-11 . This antibody is tested and proven to work in the following applications:

IL-11 Polyclonal Antibody

ES5892-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against IL-11 from Human/Mouse/Rat. This antibody is tested and validated for IHC, WB, ELISA

IL-11 Polyclonal Antibody

ES5892-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against IL-11 from Human/Mouse/Rat. This antibody is tested and validated for IHC, WB, ELISA

IL-11 Polyclonal Antibody

ABP54893-003ml 0.03ml
EUR 158
  • Immunogen information: Synthesized peptide derived from the N-terminal region of human IL-11
  • Applications tips:
Description: A polyclonal antibody for detection of IL-11 from Human, Mouse, Rat. This IL-11 antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the N-terminal region of human IL-11

IL-11 Polyclonal Antibody

ABP54893-01ml 0.1ml
EUR 289
  • Immunogen information: Synthesized peptide derived from the N-terminal region of human IL-11
  • Applications tips:
Description: A polyclonal antibody for detection of IL-11 from Human, Mouse, Rat. This IL-11 antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the N-terminal region of human IL-11

IL-11 Polyclonal Antibody

ABP54893-02ml 0.2ml
EUR 414
  • Immunogen information: Synthesized peptide derived from the N-terminal region of human IL-11
  • Applications tips:
Description: A polyclonal antibody for detection of IL-11 from Human, Mouse, Rat. This IL-11 antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the N-terminal region of human IL-11

Anti-IL-11 antibody

STJ93674 200 µl
EUR 197
Description: Rabbit polyclonal to IL-11.

Anti-IL-11 antibody

STJ98168 100 µl
EUR 234
Description: Mouse monoclonal to IL-11.

Individual Reaction Mix 11

G065-11 200 reactions
EUR 167

Human IL-11(Interleukin 11) ELISA Kit

EH0174 96T
EUR 476.25
  • Detection range: 31.25-2000 pg/ml
  • Uniprot ID: P20809
  • Alias: IL-11(Interleukin 11)
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 18.75pg/ml

Mouse Interleukin 11(IL-11)ELISA Kit    

GA-E0043MS-48T 48T
EUR 336

Mouse Interleukin 11(IL-11)ELISA Kit    

GA-E0043MS-96T 96T
EUR 534

Rat Interleukin 11(IL-11)ELISA Kit

GA-E0118RT-48T 48T
EUR 317

Rat Interleukin 11(IL-11)ELISA Kit

GA-E0118RT-96T 96T
EUR 496

Human Interleukin 11(IL-11)ELISA Kit

GA-E0141HM-48T 48T
EUR 289

Human Interleukin 11(IL-11)ELISA Kit

GA-E0141HM-96T 96T
EUR 466

Rat IL-11(Interleukin-11) ELISA Kit

ER0093 96T
EUR 524.1
  • Detection range: 15.625-1000 pg/ml
  • Uniprot ID: Q99MF5
  • Alias: IL-11/AGIF/Adipogenesis inhibitory factor/AGIFoprelvekin/IL-11Oprelvekin/interleukin 11/interleukin-11
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Rattus;Sensitivity: 9.375pg/ml

Mouse Il-11(Interleukin-11) ELISA Kit

EM0225 96T
EUR 524.1
  • Detection range: 15.625-1000 pg/ml
  • Uniprot ID: P47873
  • Alias: Il-11
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Mus ;Sensitivity: 9.375pg/ml

Human Interleukin 11 (IL-11) CLIA Kit

abx197185-96tests 96 tests
EUR 825
  • Shipped within 5-12 working days.

Mouse Interleukin 11 (IL-11) CLIA Kit

abx197186-96tests 96 tests
EUR 825
  • Shipped within 5-12 working days.

Rat Interleukin 11 (IL-11) CLIA Kit

abx197187-96tests 96 tests
EUR 825
  • Shipped within 5-12 working days.

Human Interleukin 11,IL-11 ELISA KIT

201-12-0102 96 tests
EUR 440
  • This Interleukin 11 ELISA kit is validated to work with samples from whole blood, serum, plasma and cell culture supernatant.
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Rat Interleukin 11, IL-11 ELISA KIT

CSB-E07358r-24T 1 plate of 24 wells
EUR 165
  • Sample volume: 50-100ul
  • Detection wavelength: 450nm
  • Assay performance time: 1 to 4 hours.
Description: Quantitativesandwich ELISA kit for measuring Rat Interleukin 11, IL-11 in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Rat Interleukin 11, IL-11 ELISA KIT

1-CSB-E07358r
  • EUR 703.00
  • EUR 4843.00
  • EUR 2570.00
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
  • Sample volume: 50-100ul
  • Detection wavelength: 450nm
  • Assay performance time: 1 to 4 hours.
Description: Quantitativesandwich ELISA kit for measuring Rat Interleukin 11, IL-11 in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Human Interleukin 11, IL-11 ELISA KIT

CSB-E04596h-24T 1 plate of 24 wells
EUR 165
  • Sample volume: 50-100ul
  • Detection wavelength: 450nm
  • Assay performance time: 1 to 4 hours.
Description: Quantitativesandwich ELISA kit for measuring Human Interleukin 11, IL-11 in samples from serum, cell culture supernates, urine, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Human Interleukin 11, IL-11 ELISA KIT

1-CSB-E04596h
  • EUR 602.00
  • EUR 4238.00
  • EUR 2256.00
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
  • Sample volume: 50-100ul
  • Detection wavelength: 450nm
  • Assay performance time: 1 to 4 hours.
Description: Quantitativesandwich ELISA kit for measuring Human Interleukin 11, IL-11 in samples from serum, cell culture supernates, urine, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Mouse Interleukin 11, IL-11 ELISA KIT

CSB-E04597m-24T 1 plate of 24 wells
EUR 165
  • Sample volume: 50-100ul
  • Detection wavelength: 450nm
  • Assay performance time: 1 to 4 hours.
Description: Quantitativesandwich ELISA kit for measuring Mouse Interleukin 11, IL-11 in samples from serum, plasma, cell culture supernates, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Mouse Interleukin 11, IL-11 ELISA KIT

1-CSB-E04597m
  • EUR 603.00
  • EUR 4247.00
  • EUR 2260.00
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
  • Sample volume: 50-100ul
  • Detection wavelength: 450nm
  • Assay performance time: 1 to 4 hours.
Description: Quantitativesandwich ELISA kit for measuring Mouse Interleukin 11, IL-11 in samples from serum, plasma, cell culture supernates, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Rat Interleukin 11,IL-11 ELISA KIT

CN-01551R1 96T
EUR 449

Rat Interleukin 11,IL-11 ELISA KIT

CN-01551R2 48T
EUR 299

Mouse Interleukin 11,IL-11 ELISA KIT

CN-02458M1 96T
EUR 447

Mouse Interleukin 11,IL-11 ELISA KIT

CN-02458M2 48T
EUR 296

Human Interleukin 11,IL-11 ELISA KIT

CN-03220H1 96T
EUR 434

Human Interleukin 11,IL-11 ELISA KIT

CN-03220H2 48T
EUR 284

Human Interleukin-11 (IL-11) ELISA Kit

LF-EK60040 1×96T
EUR 790

Human Interleukin 11(IL-11)ELISA Kit

QY-E04330 96T
EUR 400

Rat Interleukin 11(IL-11)ELISA Kit

QY-E11535 96T
EUR 361

Mouse Interleukin 11(IL-11)ELISA Kit

QY-E20831 96T
EUR 361

ELISA kit for Human IL-11 (Interleukin 11)

E-EL-H5022 1 plate of 96 wells
EUR 534
  • Gentaur's IL-11 ELISA kit utilizes the Sandwich-ELISA principle. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to Human IL-11. Standards or samples are added to the micro ELISA plate wells and combined with
  • Show more
Description: A sandwich ELISA kit for quantitative measurement of Human IL-11 (Interleukin 11) in samples from Serum, Plasma, Cell supernatant

ELISA kit for Mouse IL-11 (Interleukin 11)

E-EL-M0725 1 plate of 96 wells
EUR 534
  • Gentaur's IL-11 ELISA kit utilizes the Sandwich-ELISA principle. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to Mouse IL-11. Standards or samples are added to the micro ELISA plate wells and combined with
  • Show more
Description: A sandwich ELISA kit for quantitative measurement of Mouse IL-11 (Interleukin 11) in samples from Serum, Plasma, Cell supernatant

CLIA kit for Human IL-11 (Interleukin 11)

E-CL-H1450 1 plate of 96 wells
EUR 584
  • Gentaur's IL-11 CLIA kit utilizes the Sandwich- CLIA principle. The micro CLIA plate provided in this kit has been pre-coated with an antibody specific to Human IL-11 . Standards or samples are added to the micro CLIA plate wells and combined with th
  • Show more
Description: A sandwich CLIA kit for quantitative measurement of Human IL-11 (Interleukin 11) in samples from Serum, Plasma, Cell supernatant

CLIA kit for Mouse IL-11 (Interleukin 11)

E-CL-M0458 1 plate of 96 wells
EUR 584
  • Gentaur's IL-11 CLIA kit utilizes the Sandwich- CLIA principle. The micro CLIA plate provided in this kit has been pre-coated with an antibody specific to Mouse IL-11 . Standards or samples are added to the micro CLIA plate wells and combined with th
  • Show more
Description: A sandwich CLIA kit for quantitative measurement of Mouse IL-11 (Interleukin 11) in samples from Serum, Plasma, Cell supernatant

ELISA kit for Rat IL-11 (Interleukin 11)

E-EL-R0562 1 plate of 96 wells
EUR 534
  • Gentaur's IL-11 ELISA kit utilizes the Sandwich-ELISA principle. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to Rat IL-11. Standards or samples are added to the micro ELISA plate wells and combined with th
  • Show more
Description: A sandwich ELISA kit for quantitative measurement of Rat IL-11 (Interleukin 11) in samples from Serum, Plasma, Cell supernatant

CLIA kit for Rat IL-11 (Interleukin 11)

E-CL-R0396 1 plate of 96 wells
EUR 584
  • Gentaur's IL-11 CLIA kit utilizes the Sandwich- CLIA principle. The micro CLIA plate provided in this kit has been pre-coated with an antibody specific to Rat IL-11 . Standards or samples are added to the micro CLIA plate wells and combined with the
  • Show more
Description: A sandwich CLIA kit for quantitative measurement of Rat IL-11 (Interleukin 11) in samples from Serum, Plasma, Cell supernatant

Human IL-11 ELISA Kit

EHI0359 96Tests
EUR 521

Goat IL-11 ELISA Kit

EGTI0359 96Tests
EUR 521

Bovine IL-11 ELISA Kit

EBI0359 96Tests
EUR 521

Canine IL-11 ELISA Kit

ECI0359 96Tests
EUR 521

Chicken IL-11 ELISA Kit

ECKI0359 96Tests
EUR 521

IL-11 (Human) ELISA Kit

E4283-100
EUR 729

Anserini IL-11 ELISA Kit

EAI0359 96Tests
EUR 521

IL-11 ELISA KIT|Human

EF000143 96 Tests
EUR 689

Porcine IL-11 ELISA Kit

EPI0359 96Tests
EUR 521

Rat IL-11 ELISA Kit

ERI0359 96Tests
EUR 521

Rabbit IL-11 ELISA Kit

ERTI0359 96Tests
EUR 521

Sheep IL-11 ELISA Kit

ESI0359 96Tests
EUR 521

IL-11 (CHO-expressed), Human

HY-P7031A 10ug
EUR 268

IL-11 (HEK293-expressed), Mouse

HY-P7075A 50ug
EUR 843

Mouse IL-11 ELISA Kit

EMI0359 96Tests
EUR 521

Monkey IL-11 ELISA Kit

EMKI0359 96Tests
EUR 521

Anti-IL-11 Monoclonal Antibody

A01160 100ul
EUR 397
Description: Mouse Monoclonal Antibody for IL-11 Antibody (IL11) detection. Tested with WB in Human.

Human IL-11 ELISA Kit

LF-EK50831 1×96T
EUR 648

Mouse IL-11 ELISA Kit

RK00155 96 Tests
EUR 521

Human IL-11 ELISA Kit

RK00205 96 Tests
EUR 521

Anti-IL-11 alpha antibody

STJ93675 200 µl
EUR 197
Description: Rabbit polyclonal to IL-11Ralpha.

IL-11 ELISA Kit| Rat Interleukin-11 ELISA Kit

EF017069 96 Tests
EUR 689

Il-11 ELISA Kit| Mouse Interleukin-11 ELISA Kit

EF012944 96 Tests
EUR 689

ELISA kit for Human IL-11

EK5172 96 tests
EUR 469
Description: Enzyme-linked immunosorbent assay kit for quantification of Human IL-11 in samples from serum, plasma, tissue homogenates and other biological fluids.

ELISA kit for Mouse IL-11

EK5173 96 tests
EUR 519
Description: Enzyme-linked immunosorbent assay kit for quantification of Mouse IL-11 in samples from serum, plasma, tissue homogenates and other biological fluids.

Human IL-11 PicoKine ELISA Kit

EK0419 96 wells
EUR 425
Description: For quantitative detection of human IL-11 in cell culture supernates, serum and plasma(heparin, EDTA, citrate).

Mouse IL-11 PicoKine ELISA Kit

EK0420 96 wells
EUR 425
Description: For quantitative detection of mouse IL-11 in cell culture supernates, serum and plasma(heparin, EDTA, citrate).

Guinea Pig IL-11 ELISA Kit

EGI0359 96Tests
EUR 521

Recombinant Mouse IL-23 (IL-23A&IL-12B) Protein

RP00763 10 μg
EUR 249

Recombinant Human IL-22BP/IL-22RA2 Protein

RP00192 10 μg
EUR 230

Recombinant Human IL-1RAcP/IL-1R3 Protein

RP00400 10 μg
EUR 136

Recombinant Human IL-25/IL-17E Protein

RP00406 10 μg
EUR 183

Recombinant Human IL-36Ra/IL-1F5 Protein

RP00494 10 μg
EUR 221

Recombinant Mouse IL-18/IL-1F4 Protein

RP00663 10 μg
EUR 183

Recombinant Human IL-17 (IL-17A) Protein

PROTQ16552-4 25ug
EUR 317
Description: The originally described IL-17 protein, now known as IL-17A, is a homodimer of two 136 amino acid chains, secreted by activated T-cells that act on stromal cells to induce production of proinflammatory and hematopoietic bioactive molecules.  Today, IL-17 represents a family of structurally-related cytokines that share a highly conserved C-terminal region but differ from one another in their N-terminal regions and in their distinct biological roles.  The six known members of this family, IL-17A through IL-17F, are secreted as homodimers.  IL-17A exhibits cross-species bioactivity between human and murine cells.  Recombinant human IL-17A is a 31.3 kDa disulfide-linked homodimer of two 137 amino acid polypeptide chains.

Recombinant Murine IL-17 (IL-17A) Protein

PROTQ62386-1 25ug
EUR 317
Description: The originally described IL-17 protein, now known as IL-17A, is a disulfide linked homodimer, secreted by activated T-cells that act on stromal cells to induce production of proinflammatory and hematopoietic bioactive molecules. Today, IL-17 represents a family of structurally-related cytokines that share a highly conserved C-terminal region but differ from one another in their N-terminal regions and in their distinct biological roles. The six known members of this family, IL-17A through IL-17F, are secreted as homodimers. IL-17A exhibits cross-species bioactivity between human and murine cells. Recombinant murine IL-17A is a 30.0 kDa disulfide-linked homodimer of two 133 amino acid polypeptide chains.

Goat Interleukin 10,IL-11 ELISA Kit

CN-00369S2 48T
EUR 291

Recombinant Mouse IL-1α/IL-1 alpha/IL-1F1 Protein

RP00485 10 μg
EUR 221

Recombinant Mouse IL-1b/IL-1 beta/IL-1F2 Protein

RP00486 10 μg
EUR 221

BMP-11/GDF-11, human recombinant

7155-10
EUR 240

BMP-11/GDF-11, human recombinant

7155-50
EUR 860

Recombinant human Protein Wnt-11 

P1877 100ug Ask for price
  • Uniprot ID: O96014
  • Reconstitution: Metal affinity chromatography on Fn Super Capacity Column (Nickel)
Description: Recombinant protein for human Protein Wnt-11 

Recombinant Human GDF-11 Protein

PROTO95390-2 20ug
EUR 317
Description: GDF-11 is a myostatin-homologous protein that acts as an inhibitor of nerve tissue growth. GDF-11 has been shown to suppress neurogenesis through a myostatin-like pathway, which involves arrest of progenitor cell-cycle in the G1 phase. Similarities between myostatin and GDF-11, which are 90% identical in their amino acid sequence, suggests that the regulatory mechanisms responsible for maintaining proper tissue size during neural and muscular development might be the same. Recombinant human GDF-11 is a 25.0 kDa disulfide-linked homodimer containing two 109 amino acid polypeptide chains. It is highly homologous to myostatin/GDF-8 sharing 90% amino-acid sequence identity.

IGHV3OR16-11 Recombinant Protein (Human)

RP064662 100 ug Ask for price

IGKV1OR2-11 Recombinant Protein (Human)

RP065019 100 ug Ask for price

KRTAP5-11 Recombinant Protein (Human)

RP067650 100 ug Ask for price

KRTAP10-11 Recombinant Protein (Human)

RP040528 100 ug Ask for price

KRTAP4-11 Recombinant Protein (Human)

RP040597 100 ug Ask for price

RNU6-11 Recombinant Protein (Human)

RP089019 100 ug Ask for price

Recombinant HPV-11 Protein [GST]

VAng-Lsx0267-inquire inquire Ask for price
Description: HPV type 11 [GST], recombinant protein from E. coli.

Recombinant HPV-11 E1 Protein

VAng-Wyb3006-inquire inquire Ask for price
Description: Human papillomavirus type 11 Replication protein E1, recombinant protein.

Swine TNF alpha Recombinant Protein

R00002-11 5ug/vial
EUR 259
Description: Tumor necrosis factor alpha (TNFSF2, TNF alpha) is a member of the TNF Superfamily. TNF alpha, being an endogenous pyrogen, is able to induce fever, to induce apoptotic cell death, to induce sepsis (through IL-1 & IL-6 production), to induce cachexia, induce inflammation, and to inhibit tumorigenesis and viral replication. Swine TNF alpha Recombinant Protein is purified TNF alpha (TNFSF2) produced in yeast.

Swine IFN gamma Recombinant Protein

R00393-11 5ug/vial
EUR 259
Description: IFN-gamma, or type II interferon, is a cytokine that is critical for innate and adaptive immunity against viral and intracellular bacterial infections and for tumor control. Swine IFN gamma Recombinant Protein is purified IFN gamma produced in yeast.

Recombinant Human gAcrp30/Adipolean Protein

PROTQ15848-11 25ug
EUR 317
Description: gAcrp30 is a naturally occurring globular protein, obtained by proteolytic processing of adiponectin. Adiponectin is produced and secreted exclusively by adipocytes, and is a relatively abundant plasma protein, accounting for up to 0.05% of total serum protein. Like Adiponectin, gAcrp30 is capable of decreasing hyperglycemia and reversing insulin resistance. Additionally, gAcrp30 has been shown to be an important factor in promoting fat loss by signaling muscle to absorb and burn Free-Fatty Acids (FFAs). The signaling receptors for adiponectin and gAcrp30 have recently been identified and names AdipoR1 and AdipoR2. AdipoR2 is predominantly expressed in the liver. Recombinant human gAcrp30/Adipolean is a 16.6 kDa protein consisting of 145 amino acid residues.

Recombinant Human IL-36 Beta (IL-1F8) Protein

PROTQ9NZH7-2 10ug
EUR 317
Description: The IL-1 family is comprised of 11 structurally related ligands, including recently re-named IL-36α (IL-1F6), β (IL-1F8) and γ (IL-1F9). IL-36β is highly expressed in psoriatic plaques, and at lower levels in various other tissues. IL-36β signals through the IL-1Rrp2 (IL-1R6) receptor, which is primarily expressed on certain dendritic cells. The interaction of the IL-1Rrp2 receptor with IL-36 ligands induces dendritic cell maturation and activation. IL-36β also functions as an agonist of NF-kappaB, and stimulates the production of pro-inflammatory proteins, including IL-6, IL-8, BD-2, and BD-3. Recombinant human IL-36β is a 17.3 kDa protein containing 154 amino acid residues.

Recombinant Human IL-36 Gamma (IL-1F9) Protein

PROTQ9NZH8-3 10ug
EUR 317
Description: The IL-1 family is comprised of 11 structurally related ligands, including recently re-named IL-36 α (IL-1F6), β (IL-1F8) and γ (IL-1F9). IL-36γ is highly expressed in psoriatic plaques and in tissues containing epithelial cells. IL-36γ signals through the IL-1Rrp2 (IL-1R6) receptor, which is primarily expressed on certain dendritic cells. The interaction of the IL-1Rrp2 receptor with IL-36 ligands induces dendritic cell maturation and activation. IL-36γ also functions as an agonist of NF-kappaB, and can stimulate the inflammatory response in bronchial epithelial cells. Recombinant human IL-36γ is a 17.0 kDa protein containing 152 amino acid residues.

Recombinant Mouse IL-23R/IL-23 Receptor Protein

RP00689 10 μg
EUR 174

Kallikrein-11 (Recombinant)

20-abx073448
  • EUR 3418.00
  • EUR 328.00
  • EUR 230.00
  • 1 mg
  • 20 ug
  • 5 ug
  • Shipped within 5-10 working days.

Recombinant Human IL-1 Receptor Antagonist Protein/IL-1RA/IL-1F3

C033-10ug 10ug
EUR 90
Description: Lyophilized from a 0.2 μm filtered solution of 50mM TrisHCl, 200mM NaCl, pH 7.5.

Recombinant Human IL-1 Receptor Antagonist Protein/IL-1RA/IL-1F3

C033-1mg 1mg
EUR 943
Description: Lyophilized from a 0.2 μm filtered solution of 50mM TrisHCl, 200mM NaCl, pH 7.5.

Recombinant Human IL-1 Receptor Antagonist Protein/IL-1RA/IL-1F3

C033-500ug 500ug
EUR 674
Description: Lyophilized from a 0.2 μm filtered solution of 50mM TrisHCl, 200mM NaCl, pH 7.5.

Recombinant Human IL-1 Receptor Antagonist Protein/IL-1RA/IL-1F3

C033-50ug 50ug
EUR 151
Description: Lyophilized from a 0.2 μm filtered solution of 50mM TrisHCl, 200mM NaCl, pH 7.5.

Recombinant Human IL-36 Receptor Antagonist Protein/IL-36RN/IL-1F5

C071-10ug 10ug
EUR 202
Description: Lyophilized from a 0.2 μm filtered solution of 20mM TrisHCl, 150mM NaCl, pH 7.5.

Recombinant Human IL-36 Receptor Antagonist Protein/IL-36RN/IL-1F5

C071-1mg 1mg
EUR 2283
Description: Lyophilized from a 0.2 μm filtered solution of 20mM TrisHCl, 150mM NaCl, pH 7.5.

Recombinant Human IL-36 Receptor Antagonist Protein/IL-36RN/IL-1F5

C071-500ug 500ug
EUR 1613
Description: Lyophilized from a 0.2 μm filtered solution of 20mM TrisHCl, 150mM NaCl, pH 7.5.

Recombinant Human IL-36 Receptor Antagonist Protein/IL-36RN/IL-1F5

C071-50ug 50ug
EUR 496
Description: Lyophilized from a 0.2 μm filtered solution of 20mM TrisHCl, 150mM NaCl, pH 7.5.

Recombinant Mouse IL-1 Receptor Antagonist Protein/IL-1ra/IL-1RA

CK20-10ug 10ug
EUR 202
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.

Recombinant Mouse IL-1 Receptor Antagonist Protein/IL-1ra/IL-1RA

CK20-1mg 1mg
EUR 2486
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.

Recombinant Mouse IL-1 Receptor Antagonist Protein/IL-1ra/IL-1RA

CK20-500ug 500ug
EUR 1755
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.

Recombinant Mouse IL-1 Receptor Antagonist Protein/IL-1ra/IL-1RA

CK20-50ug 50ug
EUR 496
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.

IL-11 ELISA Kit (Human) : 96 Wells (OKAG00130)

OKAG00130 96 Wells
EUR 596
Description: Description of target: The protein encoded by this gene is a member of the gp130 family of cytokines. These cytokines drive the assembly of multisubunit receptor complexes, all of which contain at least one molecule of the transmembrane signaling receptor IL6ST (gp130). This cytokine is shown to stimulate the T-cell-dependent development of immunoglobulin-producing B cells. It is also found to support the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.;Species reactivity: Human;Application: ELISA;Assay info: Quantitative Colorimentric Sandwich ELISA;Sensitivity: 32 pg/mL

IL-10, human recombinant protein

P1028-.01 10 µg
EUR 300
Description: Interleukin-10 (IL-10) is an immunosuppressive cytokine produced by macrophages, monocytes, T cells, B cells and keratinocytes. IL-10 inhibits the synthesis of proinflammatory cytokines such as IL-1 and TNF-? and proliferation of T cells

IL-10, human recombinant protein

P1028-.05 50 µg
EUR 877
Description: Interleukin-10 (IL-10) is an immunosuppressive cytokine produced by macrophages, monocytes, T cells, B cells and keratinocytes. IL-10 inhibits the synthesis of proinflammatory cytokines such as IL-1 and TNF-? and proliferation of T cells

IL-10, human recombinant protein

P1028-1 1 mg
EUR 6731
Description: Interleukin-10 (IL-10) is an immunosuppressive cytokine produced by macrophages, monocytes, T cells, B cells and keratinocytes. IL-10 inhibits the synthesis of proinflammatory cytokines such as IL-1 and TNF-? and proliferation of T cells

IL-15, human recombinant protein

P1029-.01 10 µg
EUR 300
Description: Interleukin 15 (IL-15) is an immunomodulating cytokine mainly produced by adherent peripheral blood mononuclear cells, fibroblasts and epithelial cells and stimulates the proliferation of T lymphocytes.

IL-15, human recombinant protein

P1029-.05 50 µg
EUR 877
Description: Interleukin 15 (IL-15) is an immunomodulating cytokine mainly produced by adherent peripheral blood mononuclear cells, fibroblasts and epithelial cells and stimulates the proliferation of T lymphocytes.

IL-15, human recombinant protein

P1029-1 1 mg
EUR 5339
Description: Interleukin 15 (IL-15) is an immunomodulating cytokine mainly produced by adherent peripheral blood mononuclear cells, fibroblasts and epithelial cells and stimulates the proliferation of T lymphocytes.

The compound includes a nicotinonitrile scaffold with micromolar affinity and efficiency for the cytokine, and disrupts sort II IL-Four signaling in cells. Small-molecule inhibitors of those necessary cell-signaling proteins have implications for numer-ous immune-related problems and informs future drug discovery and design efforts for these chal-lenging protein targets.

Leave a Reply