Interleukin 4 Affects Epilepsy by Regulating Glial Cells: Potential and Possible Mechanism

Interleukin 4 Affects Epilepsy by Regulating Glial Cells: Potential and Possible Mechanism

Epilepsy is a persistent mind dysfunction induced by an irregular neuronal discharge that’s brought on by sophisticated psychopathologies. Not too long ago, accumulating research have revealed a detailed relationship between irritation and epilepsy.

Particularly, microglia and astrocytes are vital inflammatory cells within the central nervous system (CNS) which were confirmed to be associated to the pathogenesis and improvement of epilepsy. Moreover, interleukin 4 (IL-4) is an anti-inflammatory issue that may regulate microglia and astrocytes in lots of features. This evaluation article focuses on the regulatory function of IL-Four within the pathological adjustments of glial cells associated to epilepsy. We moreover suggest that IL-Four could play a protecting function in epileptogenesis and recommend that IL-Four could also be a novel therapeutic goal for the therapy of epilepsy.

An <em>Interleukin</em>-<em>4</em>-Loaded Bi-layer 3D Printed Scaffold Promotes Osteochondral Regeneration

Multilayer scaffolds fabricated by 3D printing or different methods have been used to restore osteochondral defects. Nonetheless, it stays a problem to regenerate the articular cartilage and subchondral bone concurrently with greater efficiency. Within the current examine, we enhanced the restore effectivity of osteochondral defects by creating a bi-layer scaffold: an interleukin-4 (IL-4)-loaded radially oriented gelatin methacrylate (GelMA) scaffold printed with digital gentle processing (DLP) within the higher layer and a porous polycaprolactone and hydroxyapatite (PCL-HA) scaffold printed with fused deposition modeling (FDM) within the decrease layer.

An in vitro check confirmed that each layers supported cell adhesion and proliferation, because the decrease layer promoted osteogenic differentiation and the higher layer with IL-Four relieved the unfavourable results of irritation on murine chondrocytes, which have been induced by interleukin-1β (IL-1β) and M1 macrophages. In a rabbit osteochondral defect restore mannequin, the IL-4-loaded bi-layer scaffold group obtained the best histological rating (24 ± 2) in comparison with the nontreated (11 ± 1) and pure bi-layer scaffold (16 ± 1) teams after 16 weeks of implantation, which confirmed that the IL-4-loaded bi-layer scaffold promoted regeneration of each cartilage and subchondral bone with elevated formation of neo-cartilage and neo-bone tissues. Thus, the IL-4-loaded bi-layer scaffold is a sexy candidate for restore and regeneration of osteochondral defects.

Enhancement of Immune Response and Anti-An infection of Mice by Porcine Antimicrobial Peptides and <em>Interleukin</em>-<em>4</em>/6 Fusion Gene Encapsulated in Chitosan Nanoparticles

So as to develop a novel and efficient immunoregulator to boost each the immune response and antimicrobial perform, a recombinant eukaryotic expression plasmid-pVAX1 co-expressing fusion cathelicidin antimicrobial peptides (CAMPs) and fusion porcine interleukin-4/6 gene (IL-4/6) was constructed and encapsulated in chitosan nanoparticles (CS-VAP4/6), ready by the ionotropic gelation methodology.

4-week-old feminine Kunming mice have been divided into three teams and intramuscularly injected, respectively, with CS-VAP, CS-VAP4/6, and CS-pVAX1. On 28 days post-inoculation, the mice have been challenged by intraperitoneal injection with Staphylococcus aureus (ATCC 25923) and Escherichia coli (ATCC 25922); IgG, IgG1 and IgG2a, CD4+, and CD8+ T cells elevated considerably within the VAP- and VAP4/6- handled mice, detected by ELISA and stream cytometry, correspondingly (p < 0.05). As analyzed by qPCR, expression ranges of Toll-like receptor (TLR) 1, TLR4, TLR6, TLR9, IL-1, IL-2, IL-4, IL-6, IL-7, IL-12, IL-15, IL-23, Tumor Necrosis Issue (TNF)-α, and Interferon-gamma (IFN-γ) genes have been additionally considerably up-regulated as compared with these of the management mice (p < 0.05).

Their immunological markers have been elevated considerably to completely different levels in CS-VAP4/6-treated mice in contrast with CS-VAP in numerous days post-inoculation (p < 0.05). After problem with E. coli and Staphylococcus aureus, many of the VAP- and VAP4/6- handled mice survived, and no signs of bacterial an infection have been noticed. In distinction, 80% of management mice died of an infection. Among the many handled teams, VAP4/6 had a stronger resistance towards problem with E. coli an infection. These outcomes demonstrated that the fusion gene of antimicrobial peptide and interleukin-4/6 has the promising potential as a secure and efficient immunomodulator for the management of bacterial infections.

Single immunoglobulin and Toll‑<em>interleukin</em>‑1 receptor area containing molecule protects towards extreme acute pancreatitis in vitro by negatively regulating the Toll‑like receptor‑<em>4</em> signaling pathway: A scientific and experimental examine

Single immunoglobulin and Toll‑interleukin‑1 receptor area‑containing molecule (SIGIRR) is a selected inhibitor of IL‑1R and Toll‑like receptor (TLR) signaling and thought of a possible goal for the therapy of inflammatory ailments. Pathogenic mechanisms related to the TLR4 signaling pathway have a important function within the improvement of extreme acute pancreatitis (SAP). The intention of the current examine was to find out the function of SIGIRR within the regulation of TLR4 signaling through the development of SAP. Pancreatitis‑related ascitic fluid (PAAF) was collected from sufferers with SAP.

Murine RAW264.7 macrophages have been transfected with a SIGIRR overexpression plasmid and co‑cultured with the PAAF from the donors in an effort to consider the impact of SIGIRR in vitro. The mRNA expression of TLR4, SIGIRR and different key downstream signaling molecules was quantified utilizing semi‑quantitative PCR with agarose gel electrophoresis. Moreover, the degrees of professional‑inflammatory cytokines within the tradition supernatant have been detected utilizing ELISA.

<em>Interleukin</em> <em>4</em> Affects Epilepsy by Regulating Glial Cells: Potential and Possible Mechanism

In distinction to SIGIRR, the mRNA expression ranges of TLR4, myeloid differentiation issue 88 (MyD88), IL‑1R‑related kinase‑1 (IRAK‑1) and TNF receptor‑related issue‑6 (TRAF‑6) have been considerably elevated in RAW264.7 cells following therapy with PAAF. Moreover, TLR4, MyD88, IRAK‑1 and TRAF‑6 mRNA ranges have been considerably downregulated following SIGIRR overexpression and PAAF therapy in RAW264.7 cells.

Recombinant Human Interleukin-12 /IL-12

CI58-500ug 500ug
EUR 1613
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

Recombinant Human Interleukin-12 /IL-12

CI58-50ug 50ug
EUR 496
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

IL-12, human recombinant

4161-10
EUR 267

IL-12, human recombinant

4161-100
EUR 1822

Recombinant Human IL-12

SJB12-01 20µg/vial
EUR 401

Recombinant Human IL 12-

SJB12-02 100µg/vial
EUR 720

Chicken Interleukin 12(IL-12)

QY-E80157 96T
EUR 426

Human Interleukin 12 (IL-12) CLIA Kit

abx195848-96tests 96 tests
EUR 825

Human IL-12(Interleukin 12) ELISA Kit

EH0176 96T
EUR 476.25
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 9.375pg/ml

Human Interleukin-12 (IL-12) ELISA Kit

LF-EK60032 1×96T
EUR 790

IL-12/P40/ Rat IL- 12/ P40 ELISA Kit

ELA-E0058r 96 Tests
EUR 886

IL-12/P70/ Rat IL- 12/ P70 ELISA Kit

ELA-E0059r 96 Tests
EUR 886

IL-12 (HEK293-expressed), Human

HY-P7032 50ug
EUR 762

Human IL-12 ELISA Kit

EHI0040 96Tests
EUR 521

Recombinant Human IL-12 Protein

RP01232 10 μg
EUR 183

Recombinant Human IL-12 Protein

PROTP29459-1 10ug
EUR 317
Description: IL-12 is a potent regulator of cell mediated immune responses and it induces IFN-γ production by NK and T cells. It is produced by activated monocytes/macrophage cells, B lymphocytes and connective tissue type mast cells. Among its biological activities IL-12 promotes the growth and activity of activated NK, CD4+ and CD8+ cells and induces the development of IFN-γ producing Th1 cells. Recombinant Human IL-12 is a 75.0 kDa heterodimeric glycoprotein consisting of disulfide-linked 35 kDa (p35) and 40 kDa (p40) subunits (503 total amino acid residues).

IL-12 ELISA KIT|Human

EF000145 96 Tests
EUR 689

IL-12 (Human) ELISA Kit

K4226-100
EUR 729

IL-12 (Interleukin 12) GMP, CF

PR15128CF 25 ug
EUR 1993

Recombinant Mouse Interleukin-12/IL-12

CM39-10ug 10ug
EUR 202
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Recombinant Mouse Interleukin-12/IL-12

CM39-1mg 1mg
EUR 2486
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Recombinant Mouse Interleukin-12/IL-12

CM39-500ug 500ug
EUR 1755
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Recombinant Mouse Interleukin-12/IL-12

CM39-50ug 50ug
EUR 496
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

99445-12 DCT 12 X 75MM

99445-12 250/pk
EUR 67
Description: Disposable Culture Tubes; DCT's, CGW

ELISA kit for Human IL-12 (Interleukin 12)

E-EL-H0150 1 plate of 96 wells
EUR 377
Description: A sandwich ELISA kit for quantitative measurement of Human IL-12 (Interleukin 12) in samples from Serum, Plasma, Cell supernatant

Human Interleukin 12(IL-12/P70)ELISA Kit

GA-E0139HM-48T 48T
EUR 289

Human Interleukin 12(IL-12/P70)ELISA Kit

GA-E0139HM-96T 96T
EUR 466

Human Interleukin 12(IL-12/P40)ELISA Kit

GA-E0140HM-48T 48T
EUR 289

Human Interleukin 12(IL-12/P40)ELISA Kit

GA-E0140HM-96T 96T
EUR 466

CLIA kit for Human IL-12 (Interleukin 12)

E-CL-H0142 1 plate of 96 wells
EUR 584
Description: A sandwich CLIA kit for quantitative measurement of Human IL-12 (Interleukin 12) in samples from Serum, Plasma, Cell supernatant

Human Interleukin 12, IL-12/P40 ELISA KIT

CSB-E04598h-24T 1 plate of 24 wells
EUR 165
Description: Quantitativesandwich ELISA kit for measuring Human Interleukin 12, IL-12/P40 in samples from serum, plasma, cell culture supernates, urine, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Human Interleukin 12, IL-12/P40 ELISA KIT

1-CSB-E04598h
  • EUR 602.00
  • EUR 4238.00
  • EUR 2256.00
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Human Interleukin 12, IL-12/P40 in samples from serum, plasma, cell culture supernates, urine, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Human Interleukin 12, IL-12/P70 ELISA KIT

CSB-E04599h-24T 1 plate of 24 wells
EUR 165
Description: Quantitativesandwich ELISA kit for measuring Human Interleukin 12, IL-12/P70 in samples from serum, cell culture supernates, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Human Interleukin 12, IL-12/P70 ELISA KIT

1-CSB-E04599h
  • EUR 603.00
  • EUR 4247.00
  • EUR 2260.00
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Human Interleukin 12, IL-12/P70 in samples from serum, cell culture supernates, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Human Interleukin 12(IL-12/P70)ELISA Kit

QY-E04328 96T
EUR 361

Human Interleukin 12(IL-12/P40)ELISA Kit

QY-E04329 96T
EUR 400

Human Interleukin 12,IL-12/P70 ELISA KIT

CN-03218H1 96T
EUR 438

Human Interleukin 12,IL-12/P70 ELISA KIT

CN-03218H2 48T
EUR 289

Human Interleukin 12,IL-12/P40 ELISA KIT

CN-03219H1 96T
EUR 438

Human Interleukin 12,IL-12/P40 ELISA KIT

CN-03219H2 48T
EUR 289

Human Interleukin 12,IL-12/P70 ELISA kit

E01I0432-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Human Interleukin 12,IL-12/P70 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Interleukin 12,IL-12/P70 ELISA kit

E01I0432-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Human Interleukin 12,IL-12/P70 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Interleukin 12,IL-12/P70 ELISA kit

E01I0432-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Human Interleukin 12,IL-12/P70 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human IL-12/IL-23 p40 ELISA Kit

RK00013 96 Tests
EUR 521

Human 12-lipoxygenase,LOX-12 ELISA Kit

201-12-0949 96 tests
EUR 440
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Human CellExp? IL-12, Human Recombinant

6467-10
EUR 343

Human CellExp? IL-12, Human Recombinant

6467-50
EUR 1333

Polyclonal IL-12 Antibody

APG00003G 0.1mg
EUR 484
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human IL-12 . This antibody is tested and proven to work in the following applications:

rHu IL-12 (cGMP)

AK9995-0000 1mg Ask for price

rHu IL-12 (cGMP)

AK9995-0100 100ug Ask for price

IL-12, rat recombinant

4163-10 Ask for price

IL-12, rat recombinant

4163-100 Ask for price

IL-12 Recombinant Protein

40-255-0002mg 0.002 mg
EUR 259.25
Description: IL-12 is a potent regulator of cell mediated immune responses and it induces IFN-γ production by NK and T cells. It is produced by activated monocytes/macrophage cells, B lymphocytes and connective tissue type mast cells. Among its biological activities IL-12 promotes the growth and activity of activated NK, CD4+ and CD8+ cells and induces the development of IFN-γ producing Th1 cells. Recombinant Human IL-12 is a 75.0 kDa heterodimeric glycoprotein consisting of disulfide-linked 35 kDa (p35) and 40 kDa (p40) subunits (503 total amino acid residues).

IL-12 Recombinant Protein

40-255-001mg 0.01 mg
EUR 364.25
Description: IL-12 is a potent regulator of cell mediated immune responses and it induces IFN-γ production by NK and T cells. It is produced by activated monocytes/macrophage cells, B lymphocytes and connective tissue type mast cells. Among its biological activities IL-12 promotes the growth and activity of activated NK, CD4+ and CD8+ cells and induces the development of IFN-γ producing Th1 cells. Recombinant Human IL-12 is a 75.0 kDa heterodimeric glycoprotein consisting of disulfide-linked 35 kDa (p35) and 40 kDa (p40) subunits (503 total amino acid residues).

IL-12 Recombinant Protein

40-419-0002mg 0.002 mg
EUR 259.25
Description: IL-12 is a potent regulator of cell mediated immune responses and it induces IFN-gamma production by NK and T cells. It is produced by activated monocytes/macrophage cells, B lymphocytes and connective tissue type mast cells. Among its biological activities IL-12 promotes the growth and activity of activated NK, CD4+ and CD8+ cells and induces the development of IFN-gamma producing Th1 cells. Recombinant murine IL-12 is a 75.0 kDa heterodimeric glycoprotein consisting of disulfide-linked 35 kDa (p35) and 40 kDa (p40) subunits (506 total amino acid residues).

IL-12 Recombinant Protein

40-419-001mg 0.01 mg
EUR 364.25
Description: IL-12 is a potent regulator of cell mediated immune responses and it induces IFN-gamma production by NK and T cells. It is produced by activated monocytes/macrophage cells, B lymphocytes and connective tissue type mast cells. Among its biological activities IL-12 promotes the growth and activity of activated NK, CD4+ and CD8+ cells and induces the development of IFN-gamma producing Th1 cells. Recombinant murine IL-12 is a 75.0 kDa heterodimeric glycoprotein consisting of disulfide-linked 35 kDa (p35) and 40 kDa (p40) subunits (506 total amino acid residues).

IL-12 Recombinant Protein

40-520-0002mg 0.002 mg
EUR 259.25
Description: IL-12 is a disulfide-linked heterodimeric protein (p70), composed of two subunits, p35 and p40, which are encoded by two different genes. Accumulating data indicate that p40 secretion precedes that of IL-12 expression. In addition, to its ability to covalently bind to p35 to form IL-12, p40 can bind to p19 to form IL-23, or can form a homodimer designated as IL-12 p80. Elevated levels of IL-12 p80 are correlated with macrophage recruitment and increased inflammation in asthma and respiratory viral infection models. Recombinant human IL-12 p80 is an 80.0 kDa disulfide linked homodimer consisting of two p40 chains of IL-12.

IL-12 Recombinant Protein

40-520-001mg 0.01 mg
EUR 364.25
Description: IL-12 is a disulfide-linked heterodimeric protein (p70), composed of two subunits, p35 and p40, which are encoded by two different genes. Accumulating data indicate that p40 secretion precedes that of IL-12 expression. In addition, to its ability to covalently bind to p35 to form IL-12, p40 can bind to p19 to form IL-23, or can form a homodimer designated as IL-12 p80. Elevated levels of IL-12 p80 are correlated with macrophage recruitment and increased inflammation in asthma and respiratory viral infection models. Recombinant human IL-12 p80 is an 80.0 kDa disulfide linked homodimer consisting of two p40 chains of IL-12.

IL-12 Recombinant Protein

90-502 25 ug
EUR 569
Description: Interleukin-12 (IL-12), also known as Natural Killer Cell Stimulatory Factor (NKSF) or Cytotoxic Lymphocyte Maturation Factor (CLMF), is a heterodimeric pleiotropic cytokine made up of a 40 kDa (p40) subunit and a 35 kDa (p35) subunit. IL-12 is produced by macrophages and B lymphocytes and has been shown to have multiple effects on T cells and Natural Killer (NK) cells. Some of these IL-12 activities include the induction of IFN-gamma and TNF in resting and activated T and NK cells; the enhancement of cytotoxic activity of resting NK and T cells, the stimulation of resting T cell proliferation in the presence of a comitogen; and the enhancement of NK cell proliferation. Current evidence indicates that IL-12 is a key mediator of cellular immunity and induces the differentiation of Th1 cells from precursor T helper cells. Based on its activities, it has been suggested that IL-12 may have therapeutic potential as a vaccine adjuvant that promotes cellular immunity and as an antitumor and anti viral agent.

IL-12 Recombinant Protein

90-503 25 ug
EUR 569
Description: Interleukin-12 (IL-12), also known as Natural Killer Cell Stimulatory Factor (NKSF) or Cytotoxic Lymphocyte Maturation Factor (CLMF), is a heterodimeric pleiotropic cytokine made up of a 40 kDa (p40) subunit and a 35 kDa (p35) subunit. IL-12 is produced by macrophages and B lymphocytes and has been shown to have multiple effects on T cells and Natural Killer (NK) cells. Some of these IL-12 activities include the induction of IFN-gamma and TNF in resting and activated T and NK cells; the enhancement of cytotoxic activity of resting NK and T cells, the stimulation of resting T cell proliferation in the presence of a comitogen; and the enhancement of NK cell proliferation. Current evidence indicates that IL-12 is a key mediator of cellular immunity and induces the differentiation of Th1 cells from precursor T helper cells. Based on its activities, it has been suggested that IL-12 may have therapeutic potential as a vaccine adjuvant that promotes cellular immunity and as an antitumor and anti viral agent.

IL-12 Recombinant Protein

92-363 0.05 mg
EUR 684.5
Description: IL-12 is involved in the differentiation of naive T cells into Th1 cells. It is known as a T cell-stimulating factor, which can stimulate the growth and function of T cells. It stimulates the production of interferon-gamma (IFN- gamma ) and tumor necrosis factor-alpha (TNF- alpha) from T cells and natural killer (NK) cells, and reduces IL-4 mediated suppression of IFN- gamma . T cells that produce IL-12 have a coreceptor, CD30, which is associated with IL-12 activity.IL-12 plays an important role in the activities of natural killer cells and T lymphocytes. IL-12 mediates enhancement of the cytotoxic activity of NK cells and CD8+ cytotoxic T lymphocytes.

IL-12 Recombinant Protein

92-631 0.05 mg
EUR 684.5
Description: IL-12 is involved in the differentiation of naive T cells into Th1 cells. It is known as a T cell-stimulating factor, which can stimulate the growth and function of T cells. It stimulates the production of interferon-gamma (IFN- gamma ) and tumor necrosis factor-alpha (TNF- alpha) from T cells and natural killer (NK) cells, and reduces IL-4 mediated suppression of IFN- gamma . T cells that produce IL-12 have a coreceptor, CD30, which is associated with IL-12 activity. IL-12 plays an important role in the activities of natural killer cells and T lymphocytes. IL-12 mediates enhancement of the cytotoxic activity of NK cells and CD8+ cytotoxic T lymphocytes.

Mouse Interleukin 12 (IL-12) CLIA Kit

abx195846-96tests 96 tests
EUR 825

Rat Interleukin 12 (IL-12) CLIA Kit

abx195847-96tests 96 tests
EUR 825

Hamster IL-12(Interleukin 12) ELISA Kit

EHA0002 96T
EUR 567.6
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Hamster ;Sensitivity: 9.375pg/ml

Mouse IL-12(Interleukin 12) ELISA Kit

EM1528 96T
EUR 524.1
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Mus ;Sensitivity: 4.688pg/ml

Monkey IL-12(Interleukin 12) ELISA Kit

EMK0037 96T
EUR 567.6
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Ape;Sensitivity: 9.375pg/ml

Rat IL-12(Interleukin 12) ELISA Kit

ER1086 96T
EUR 476.25
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Rattus;Sensitivity: 9.375pg/ml

Bovine Interleukin 12, IL-12 ELISA Kit

CSB-E14010B-24T 1 plate of 24 wells
EUR 165
Description: Quantitativesandwich ELISA kit for measuring Bovine Interleukin 12, IL-12 in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Bovine Interleukin 12, IL-12 ELISA Kit

1-CSB-E14010B
  • EUR 946.00
  • EUR 5782.00
  • EUR 3060.00
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Bovine Interleukin 12, IL-12 in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Sheep Interleukin 12, IL-12 ELISA Kit

CSB-E14017Sh-24T 1 plate of 24 wells
EUR 165
Description: Quantitativesandwich ELISA kit for measuring Sheep Interleukin 12, IL-12 in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Sheep Interleukin 12, IL-12 ELISA Kit

1-CSB-E14017Sh
  • EUR 967.00
  • EUR 5925.00
  • EUR 3134.00
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Sheep Interleukin 12, IL-12 in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Rabbit IL-12(Interleukin 12) ELISA Kit

ERB0057 96T
EUR 567.6
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Rabbit;Sensitivity: 18.75pg/ml

Sheep IL-12(Interleukin 12) ELISA Kit

ESH0010 96T
EUR 567.6
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Sheep;Sensitivity: 18.75pg/ml

Bovine Interleukin 12(IL-12) ELISA Kit

QY-E60090 96T
EUR 426

Human Interleukin 12 p40 (IL-12 p40) CLIA Kit

abx195849-96tests 96 tests
EUR 825

Human Interleukin 12 P70 (IL-12 p70) ELISA Kit

abx251064-96tests 96 tests
EUR 637

IL-12-p35 Interleukin-12 p35 Human Recombinant Protein

PROTP29459 Regular: 10ug
EUR 317
Description: Interleukin-12 p35 His Human Recombinant produced in E.Coli is single, a non-glycosylated, polypeptide chain containing 197 amino acids fragment (57-253) with an amino-terminal hexahistidine tag. ;The IL-12 p35 His is purified by proprietary chromatographic techniques.

IL-12-p40 Interleukin-12 p40 Human Recombinant Protein

PROTP29460-2 Regular: 10ug
EUR 317
Description: Interleukin-12 p40 His Human Recombinant produced in E.Coli is single, a non-glycosylated, polypeptide chain containing 306 amino acids fragment (23-328) with an amino-terminal hexahistidine tag. ;The IL-12 p40 His is purified by proprietary chromatographic techniques.

Human IL-12(p40)(Interleukin 12 p40) ELISA Kit

EH0175 96T
EUR 476.25
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 18.75pg/ml

Human IL-12(p35)(Interleukin 12 p35) ELISA Kit

EH4146 96T
EUR 524.1
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 18.75pg/ml

Human IL-12/P70 ELISA Kit

EHI0362 96Tests
EUR 521

Anti-human IL-12 (p70) antibody

STJ15100085 250 µg
EUR 367
Description: This monoclonal antibody enables sensitive and specific detection of human IL-12 (p70) in immunoassays such as ELISA and ELISpot.

Human IL-12 p70 ELISA Kit

RK00014 96 Tests
EUR 521

Recombinant Human IL-12 p40 Protein

PROTP29460-3 10ug
EUR 317
Description: Interleukin-12 is a disulfide-linked heterodimeric protein (p70), composed of two subunits, p35 and p40, which are encoded by two different genes. Accumulating data indicate that p40 secretion precedes that of IL-12 expression. In addition to its ability to covalently bind to p35 to form IL-12, p40 can bind to p19 to form IL-23. Recombinant human IL-12 p40 is a 40 kDa protein containing 306 amino acid residues.

Recombinant Human IL-12 p80 Protein

PROTP29460-4 10ug
EUR 317
Description: IL-12 is a disulfide-linked heterodimeric protein (p70), composed of two subunits, p35 and p40, which are encoded by two different genes. Accumulating data indicate that p40 secretion precedes that of IL-12 expression. In addition, to its ability to covalently bind to p35 to form IL-12, p40 can bind to p19 to form IL-23, or can form a homodimer designated as IL-12 p80. Elevated levels of IL-12 p80 are correlated with macrophage recruitment and increased inflammation in asthma and respiratory viral infection models. Recombinant human IL-12 p80 is an 80.0 kDa disulfide linked homodimer consisting of two p40 chains of IL-12.

IL-12 p40 ELISA KIT|Human

EF000144 96 Tests
EUR 689

Human IL-12(p70) ELISA kit

LF-EK50181 1×96T
EUR 648

IL-12 p35 ELISA KIT|Human

EF007351 96 Tests
EUR 689

Human CellExp? IL-12, Mouse Recombinant

4719-10
EUR 392

Human CellExp? IL-12, Mouse Recombinant

4719-100
EUR 2785

Recombinant Human IL-12RB1/IL-12 R beta 1/IL-12RB Protein

RP00675 10 μg
EUR 145

ELISA kit for Mouse IL-12 (Interleukin 12)

E-EL-M0726 1 plate of 96 wells
EUR 377
Description: A sandwich ELISA kit for quantitative measurement of Mouse IL-12 (Interleukin 12) in samples from Serum, Plasma, Cell supernatant

ELISA kit for Porcine IL-12 (Interleukin 12)

E-EL-P0455 1 plate of 96 wells
EUR 584
Description: A sandwich ELISA kit for quantitative measurement of Porcine IL-12 (Interleukin 12) in samples from Serum, Plasma, Cell supernatant

The degrees of IL‑2, IL‑12, IL‑17 and IFN‑γ within the tradition supernatant have been additionally considerably decreased, whereas IL‑10 ranges have been elevated. General, SIGIRR negatively regulated the TLR4 signaling pathway to guard towards the event of SAP in an in vitro mannequin. Subsequently, SIGIRR could characterize a promising therapeutic goal for SAP.

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